Abstract:
:The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2-3% of adults and often precedes the development of allergic rhinitis and asthma. This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Le Lamer M,Pellerin L,Reynier M,Cau L,Pendaries V,Leprince C,Méchin MC,Serre G,Paul C,Simon Mdoi
10.1515/hsz-2015-0141subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1163-79issue
11eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2015-0141/hsz-2015-0141.journal_volume
396pub_type
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