Abstract:
:Human kallikrein-related peptidases (KLKs), including the well-known prostate cancer biomarker, prostate-specific antigen (PSA-KLK3), along with 14 other serine proteinase KLK family members are now known to regulate cells by cleaving and activating members of the G-protein-coupled proteinase-activated receptor (PAR) family. This hormone-like signaling action of the KLKs has provided a new perspective for understanding the biological roles that KLKs may play in normal and pathophysiological settings. This overview summarizes the circumstances leading up to the discovery of this action of the KLKs and provides an overview of the diverse impact on tissue function that may result from KLK-triggered PAR activation.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Hollenberg MDdoi
10.1515/hsz-2014-0123subject
Has Abstractpub_date
2014-09-01 00:00:00pages
915-29issue
9eissn
1431-6730issn
1437-4315pii
/j/bchm.2014.395.issue-9/hsz-2014-0123/hsz-2014-01journal_volume
395pub_type
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