Characterization of the nuclear import mechanisms of HSV-1 UL31.

Abstract:

:As an important protein, UL31 has been demonstrated to play multiple roles in herpes simplex virus 1 (HSV-1) replication. Previous studies showed that UL31 predominantly locates in the nucleus in chemical fixed cells and live cells, however, the determining mechanisms for its nuclear translocation is not clear. In the present study, by utilizing live cells fluorescent microscopy and co-immunoprecipitation assays, the nuclear import of UL31 was characterized to be dependent on Ran-, importin α1- and transportin-1-mediated pathway. Therefore, these results will promote the understanding of UL31-mediated biological functions in HSV-1 infection cycle.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Cai M,Si J,Li X,Zeng Z,Li M

doi

10.1515/hsz-2015-0299

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

555-61

issue

6

eissn

1431-6730

issn

1437-4315

pii

/j/bchm.just-accepted/hsz-2015-0299/hsz-2015-0299.

journal_volume

397

pub_type

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