Abstract:
:As an important protein, UL31 has been demonstrated to play multiple roles in herpes simplex virus 1 (HSV-1) replication. Previous studies showed that UL31 predominantly locates in the nucleus in chemical fixed cells and live cells, however, the determining mechanisms for its nuclear translocation is not clear. In the present study, by utilizing live cells fluorescent microscopy and co-immunoprecipitation assays, the nuclear import of UL31 was characterized to be dependent on Ran-, importin α1- and transportin-1-mediated pathway. Therefore, these results will promote the understanding of UL31-mediated biological functions in HSV-1 infection cycle.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Cai M,Si J,Li X,Zeng Z,Li Mdoi
10.1515/hsz-2015-0299subject
Has Abstractpub_date
2016-06-01 00:00:00pages
555-61issue
6eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2015-0299/hsz-2015-0299.journal_volume
397pub_type
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