Binding and activation of the human plasma kinin-forming system on the cell walls of Candida albicans and Candida tropicalis.

Abstract:

:Bacterial infections often upregulate the plasma kinin-forming cascade of the host (the 'contact system') which is triggered by adsorption of high molecular mass kininogen (HK), coagulation factor XII (FXII) and prekallikrein (pHPK) on the host or pathogen cell surfaces. A possible activation of the contact system upon infection of the human host by major fungal pathogens of Candida species has not been extensively explored until a recent report of tight binding of HK to the cell walls of these fungi. In the current study, the adsorption of the other contact system components to the cell surfaces of Candida albicans and Candida tropicalis was characterized. FXII was found to be tightly bound by Candida germ tube forms, to a level 5-fold higher than that for HK. In contrast, pHPK bound poorly but its additional amounts could dock to the cell wall through the surface-bound HK. It was also shown that within the complex of these proteins assembled on the cell walls of fungal hyphae, pHPK could be activated by FXIIa and the active HPK effectively produced kinins from HK. It is suggested that kinins, released at the Candida cell wall, can promote host colonization by the pathogen and the development of infection.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Karkowska-Kuleta J,Kozik A,Rapala-Kozik M

doi

10.1515/BC.2009.145

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

97-103

issue

1

eissn

1431-6730

issn

1437-4315

journal_volume

391

pub_type

杂志文章
  • Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha).

    abstract::The flagellate Euglena gracilis contains as photoreceptor complex a heterotetrameric light-sensitive adenylyl cyclase (AC), consisting of the flavoproteins PACalpha and PACbeta. Previously, we demonstrated the functional expression of PACalpha and PACbeta in oocytes from Xenopus laevis and of PACalpha in different ani...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2009.132

    authors: Looser J,Schröder-Lang S,Hegemann P,Nagel G

    更新日期:2009-11-01 00:00:00

  • Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene expression during human myoblast differentiation.

    abstract::HB13 human myoblasts express physiological and biochemical markers associated with myoblast differentiation in non-human cell culture model systems. During differentiation, HB13 myoblasts also demonstrate fusion-related increases in cathepsin B activity and protein levels. These increases are associated with an increa...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2002.207

    authors: Jane DT,Morvay LC,Koblinski J,Yan S,Saad FA,Sloane BF,Dufresne MJ

    更新日期:2002-12-01 00:00:00

  • A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration.

    abstract::We developed a novel method for the simultaneous extraction and analysis of total tissue RNA and DNA to quantify the RNA and DNA oxidation products 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine using HPLC coupled to electrochemical detection (HPLC-ECD). The protein denaturing agents guanidine thio...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2006.014

    authors: Hofer T,Seo AY,Prudencio M,Leeuwenburgh C

    更新日期:2006-01-01 00:00:00

  • Stage-specific antimalarial activity of cysteine protease inhibitors.

    abstract::Cysteine proteases of the malaria parasite Plasmodium falciparum, known as falcipains, are promising targets for antimalarial chemotherapy. We evaluated cultured parasites for the stage-specific expression of cysteine proteases and sensitivity to cysteine protease inhibitors. Protease activity and inhibitor sensitivit...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2002.089

    authors: Shenai BR,Semenov AV,Rosenthal PJ

    更新日期:2002-05-01 00:00:00

  • MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.

    abstract::A central point of regulation in the Wnt/beta-catenin signalling pathway is the formation of the beta-catenin destruction complex. Axin1, an essential negative regulator of Wnt signalling, serves as a scaffold within this complex and is critical for rapid turnover of beta-catenin. To examine the mechanism by which Wnt...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2010.028

    authors: Sue Ng S,Mahmoudi T,Li VS,Hatzis P,Boersema PJ,Mohammed S,Heck AJ,Clevers H

    更新日期:2010-02-01 00:00:00

  • Association of betaine-homocysteine S-methyltransferase with microtubules.

    abstract::In mammals, betaine of the mitochondrial matrix is used in the cytosol by betaine-homocysteine S-methyltransferase for methionine synthesis. The resulting dimethylglycine is shuttled back into the mitochondrial matrix for further degradation. Nanospray tandem mass spectrometry and N-terminal amino acid sequencing of m...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2000.080

    authors: Sandu C,Nick P,Hess D,Schiltz E,Garrow TA,Brandsch R

    更新日期:2000-07-01 00:00:00

  • Trypsin: a case study in the structural determinants of enzyme specificity.

    abstract::Trypsin and chymotrypsin have similar tertiary structures, although very different substrate specificities. Trypsin hydrolyzes peptides at Lys/Arg residues while chymotrypsin recognizes large hydrophobic residues. Recent work has shown that trypsin is not converted into a protease with chymotrypsin-like activity when ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Hedstrom L

    更新日期:1996-07-01 00:00:00

  • Towards understanding selenocysteine incorporation into bacterial proteins.

    abstract::In bacteria, UGA stop codons can be recoded to direct the incorporation of selenocysteine into proteins on the ribosome. Recoding requires a selenocysteine incorporation sequence (SECIS) downstream of the UGA codon, a specialized translation factor SelB, and the non-canonical Sec-tRNASec, which is formed from Ser-tRNA...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.108

    authors: Fischer N,Paleskava A,Gromadski KB,Konevega AL,Wahl MC,Stark H,Rodnina MV

    更新日期:2007-10-01 00:00:00

  • Evolution of ABC transporters by gene duplication and their role in human disease.

    abstract::The ATP-binding cassette (ABC) transporter genes represent the largest family of transporters and these genes are abundant in the genome of all vertebrates. Through analysis of the genome sequence databases we have characterized the full complement of ABC genes from several mammals and other vertebrates. Multiple gene...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2011.006

    authors: Moitra K,Dean M

    更新日期:2011-01-01 00:00:00

  • Structure-function relationship of bromelain isoinhibitors from pineapple stem.

    abstract::Bromelain isoinhibitors from pineapple stem (BIs) are unique double-chain inhibitors and inhibit the cysteine proteinase bromelain competitively. The three-dimensional structure was shown to be composed of two distinct domains, each of which is formed by a three-stranded anti-parallel beta-sheet. Unexpectedly, BIs wer...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2002.126

    authors: Hatano K,Sawano Y,Tanokura M

    更新日期:2002-07-01 00:00:00

  • Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements.

    abstract::Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct protein products. This is accomplished by the differential recognition of splice sites in the pre-mRNA, often regulated in a tissue- or development-specific manner. Altern...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2005.143

    authors: Hui J,Bindereif A

    更新日期:2005-12-01 00:00:00

  • Substrate specificity of glutaminyl cyclases from plants and animals.

    abstract::Glutaminyl cyclases (QC) catalyze the intramolecular cyclization of N-terminal glutamine residues of peptides and proteins. For a comparison of the substrate specificity of human and papaya QC enzymes, a novel continuous assay was established by adapting an existing discontinuous method. Specificity constants (kcat/Km...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2003.175

    authors: Schilling S,Manhart S,Hoffmann T,Ludwig HH,Wasternack C,Demuth HU

    更新日期:2003-12-01 00:00:00

  • The nanodisc: a novel tool for membrane protein studies.

    abstract::A major challenge in the research on membrane-anchored and integral membrane protein complexes is to obtain these in a functionally active, water-soluble, and monodisperse form. This requires the incorporation of the membrane proteins into a native-like membrane or detergent micelle that mimics the properties of the o...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2009.091

    authors: Borch J,Hamann T

    更新日期:2009-08-01 00:00:00

  • Rhadinoviral interferon regulatory factor homologues.

    abstract::Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2017-0111

    authors: Koch S,Schulz TF

    更新日期:2017-07-26 00:00:00

  • The YidC/Oxa1/Alb3 protein family: common principles and distinct features.

    abstract::The members of the YidC/Oxa1/Alb3 protein family are evolutionary conserved in all three domains of life. They facilitate the insertion of membrane proteins into bacterial, mitochondrial, and thylakoid membranes and have been implicated in membrane protein folding and complex formation. The major classes of substrates...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2012-0199

    authors: Saller MJ,Wu ZC,de Keyzer J,Driessen AJ

    更新日期:2012-11-01 00:00:00

  • Regulatory effect of hsa-miR-5590-3P on TGFβ signaling through targeting of TGFβ-R1, TGFβ-R2, SMAD3 and SMAD4 transcripts.

    abstract::Transforming growth factor-β (TGFβ) signaling acts as suppressor and inducer of tumor progression during the early and late stages of cancer, respectively. Some miRNAs have shown a regulatory effect on TGFβ signaling and here, we have used a combination of bioinformatics and experimental tools to show that hsa-miR-559...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2018-0264

    authors: Abedini Bakhshmand E,Soltani BM

    更新日期:2019-04-24 00:00:00

  • Switchable inteins for conditional protein splicing.

    abstract::Synthetic biologists aim at engineering controllable biological parts such as DNA, RNA and proteins in order to steer biological activities using external inputs. Proteins can be controlled in several ways, for instance by regulating the expression of their encoding genes with small molecules or light. However, post-t...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2018-0309

    authors: Di Ventura B,Mootz HD

    更新日期:2019-03-26 00:00:00

  • Tapasin and other chaperones: models of the MHC class I loading complex.

    abstract::MHC (major histocompatibility complex) class I molecules bind intracellular virus-derived peptides in the endoplasmic reticulum (ER) and present them at the cell surface to cytotoxic T lymphocytes. Peptide-free class I molecules at the cell surface, however, could lead to aberrant T cell killing. Therefore, cells ensu...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2004.100

    authors: Wright CA,Kozik P,Zacharias M,Springer S

    更新日期:2004-09-01 00:00:00

  • Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins.

    abstract::Components of kinin-forming systems operating at inflammatory sites are likely to interact with elastase that is released by recruited neutrophils and may, at least temporarily, constitute the major proteolytic activity present at these sites. The aim of this work was to determine the effect of kininogen degradation b...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2003.104

    authors: Dulinski R,Suder P,Guevara-Lora I,Rapała-Kozik M,Potempa J,Silberring J,Imamura T,Travis J,Kozik A

    更新日期:2003-06-01 00:00:00

  • Protein import: the hitchhikers guide into chloroplasts.

    abstract::Plastids originated from an endosymbiotic event between an early eukaryotic host cell and an ancestor of today's cyanobacteria. During the events by which the engulfed endosymbiont was transformed into a permanent organelle, many genes were transferred from the plastidal genome to the nucleus of the host cell. Protein...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2000.110

    authors: Vothknecht UC,Soll J

    更新日期:2000-09-01 00:00:00

  • Loss of miR-378 in prostate cancer, a common regulator of KLK2 and KLK4, correlates with aggressive disease phenotype and predicts the short-term relapse of the patients.

    abstract::A large number of prostate cancer (PCa) patients receive treatment without significant benefits, strengthening the need for accurate prognosis, which can be supported by the study of miRNAs. In silico specificity analysis was performed for the identification of miRNAs able to regulate KLK2 and KLK4 expression. Total R...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2014-0150

    authors: Avgeris M,Stravodimos K,Scorilas A

    更新日期:2014-09-01 00:00:00

  • Maintaining protein composition in cilia.

    abstract::The primary cilium is a sensory organelle that is vital in regulating several signalling pathways. Unlike most organelles cilia are open to the rest of the cell, not enclosed by membranes. The distinct protein composition is crucial to the function of cilia and many signalling proteins and receptors are specifically c...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2017-0168

    authors: Stephen LA,Elmaghloob Y,Ismail S

    更新日期:2017-12-20 00:00:00

  • Binding of 92 kDa and 72 kDa progelatinases to insoluble elastin modulates their proteolytic activation.

    abstract::92 kDa and 72 kDa gelatinases, two neutral proteinases exhibiting elastinolytic activity and secreted as zymogens by aortic smooth muscle cells, were shown to bind to insoluble elastin. The active form of each enzyme interacted with substrate more avidly than latent form. Once bound to insoluble elastin, 92 kDa progel...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.3-4.265

    authors: Emonard H,Hornebeck W

    更新日期:1997-03-01 00:00:00

  • Tailor-made dyes for fluorescence correlation spectroscopy (FCS).

    abstract::Two new fluorescent labels are presented that are optimized for excitation with He/Ne laser and red diode lasers. Application in FCS and labeling of proteins and oligomers are demonstrated. A strong rise of quantum yield and emission life time upon binding to biomolecules are characteristic features of the dyes. ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2001.062

    authors: Czerney P,Lehmann F,Wenzel M,Buschmann V,Dietrich A,Mohr GJ

    更新日期:2001-03-01 00:00:00

  • Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alpha1 chain.

    abstract::Interleukin-13 (IL-13) is a T-cell-derived pleiotropic cytokine of particular medical importance because of its critical role in the development of allergic asthma. The effects of IL-13 on its target cells are mediated through a dimeric transmembrane receptor (IL-13R), which shares the IL-4Ralpha subunit with the IL-4...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.036

    authors: Knackmuss S,Krause S,Engel K,Reusch U,Virchow JC,Mueller T,Kraich M,Little M,Luttmann W,Friedrich K

    更新日期:2007-03-01 00:00:00

  • Nervous system pathology: the fibrin perspective.

    abstract::Studies of extracellular matrix (ECM) biology in the nervous system have mainly focused on laminin, fibronectin and tenascin-R, proteins that are present during nervous system development and normal function. However, during disease, fibrin, which physiologically is not present in the nervous tissue, is detected at ne...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2002.004

    authors: Akassoglou K,Strickland S

    更新日期:2002-01-01 00:00:00

  • Mannosidase action, independent of glucose trimming, is essential for proteasome-mediated degradation of unassembled glycosylated Ig light chains.

    abstract::In order to study the role of N-glycans in the ER-associated degradation of unassembled immunoglobulin light (Ig L) chains, we introduced N-glycan acceptor sites into the variable domain of the murine Ig L chain kappaNS1, which is unfolded in unassembled molecules. We investigated the fate of kappaNS1 glycosylated at ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2000.143

    authors: Chillarón J,Adán C,Haas IG

    更新日期:2000-12-01 00:00:00

  • Hsp70 chaperone systems: diversity of cellular functions and mechanism of action.

    abstract::Hsp70 chaperone systems play an essential role in the life cycle of many proteins not only in an hostile environment but also under normal growth conditions. In the course of evolution the diversification of functions was accompanied by an amplification of components of the Hsp70 system. Here strategies are reviewed h...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Mayer MP,Bukau B

    更新日期:1998-03-01 00:00:00

  • Central nervous system: cholesterol turnover, brain development and neurodegeneration.

    abstract::The average amount of cholesterol in the whole animal equals approximately 2100 mg/kg body weight, and 15% and 23% of this sterol in the mouse and human, respectively, is found in the central nervous system. There is no detectable uptake across the blood-brain barrier of cholesterol carried in lipoproteins in the plas...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2009.035

    authors: Dietschy JM

    更新日期:2009-04-01 00:00:00

  • Differences in the activation mechanism between the alpha and beta subunits of human meprin.

    abstract::Meprins are zinc-endopeptidases of the astacin family, which are expressed as membrane-bound or secreted forms in renal and intestinal brush-border membranes of mouse, rat and man. There are two types of meprin subunits, alpha and beta, which form disulfide-bonded homo- and heterodimers; further oligomerization is med...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2003.092

    authors: Becker C,Kruse MN,Slotty KA,Köhler D,Harris JR,Rösmann S,Sterchi EE,Stöcker W

    更新日期:2003-05-01 00:00:00