Abstract:
:Zinc (Zn2+) is the most abundant trace element in cells and is essential for a vast number of catalytic, structural, and regulatory processes. Mounting evidence indicates that like calcium (Ca2+), intracellular Zn2+ pools are redistributed for specific cellular functions. This occurs through the regulation of 24 Zn2+ transporters whose localization and expression is tissue and cell specific. We propose that the complement and regulation of Zn2+ transporters expressed within a given cell type reflects the function of the cell itself and comprises a 'Zn2+ network.' Importantly, increasing information implicates perturbations in the Zn2+ network with metabolic consequences and disease. Herein, we discuss our current understanding of Zn2+ transporters from the perspective of a Zn2+ network in four specific tissues with unique Zn2+ requirements (mammary gland, prostate, pancreas, and brain). Delineating the entire Zn2+ transporting network within the context of unique cellular Zn2+ needs is important in identifying critical gaps in our knowledge and improving our understanding of the consequences of Zn2+ dysregulation in human health and disease.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Hennigar SR,Kelleher SLdoi
10.1515/hsz-2012-0128subject
Has Abstractpub_date
2012-07-01 00:00:00pages
565-78issue
7eissn
1431-6730issn
1437-4315pii
/j/bchm.2012.393.issue-7/hsz-2012-0128/hsz-2012-01journal_volume
393pub_type
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