Abstract:
:The formation of reactive oxygen species (ROS) can be induced by xenobiotic substances, such as redox cycling molecules, but also by endogenous substances such as hormones and cytokines. Recent research shows the importance of ROS in cellular signaling. Here, the signaling pathways of the two blood pressure-regulating hormones angiotensin II and aldosterone are presented, focusing on both their physiological effects and the change of signaling owing to the action of increased concentrations or prolonged exposure. When present in high concentrations, both angiotensin II and aldosterone, as various other endogenous substances, activate NADPH oxidase, which produces superoxide. In this review the generation of superoxide anions and hydrogen peroxide in cells stimulated with angiotensin II or aldosterone, as well as the subsequently induced signaling processes and DNA damage is discussed.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Queisser N,Fazeli G,Schupp Ndoi
10.1515/BC.2010.136subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1265-79issue
11eissn
1431-6730issn
1437-4315journal_volume
391pub_type
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