Abstract:
:Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct protein products. This is accomplished by the differential recognition of splice sites in the pre-mRNA, often regulated in a tissue- or development-specific manner. Alternative splicing constitutes not only an important mechanism in controlling gene expression in humans, but also an essential source for increasing proteome diversity. In this review we summarize the underlying mechanistic principles, focussing on the cis-acting regulatory elements. In particular, the role of short sequence repeats, which are often polymorphic, in splicing regulation is discussed.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Hui J,Bindereif Adoi
10.1515/BC.2005.143keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1265-71issue
12eissn
1431-6730issn
1437-4315journal_volume
386pub_type
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