Abstract:
:The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Joshi R,Feldmann V,Koestner W,Detje C,Gottschalk S,Mayer HA,Sauer MG,Engelmann Jdoi
10.1515/hsz-2012-0251subject
Has Abstractpub_date
2013-01-01 00:00:00pages
125-35issue
1eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2012-0251/hsz-2012-0251.journal_volume
394pub_type
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