Abstract:
:The signal recognition particle (SRP), a ubiquitous cytoplasmic ribonucleoprotein particle, plays an essential role in promoting co-translational translocation of proteins into the endoplasmic reticulum. Here, we summarise recent progress made in the understanding of two essential SRP functions: the signal recognition function, which ensures the specificity, and the elongation arrest function, which increases the efficiency of translocation. Our discussion is based on functional data as well as on atomic structure information, both of which also support the notion that SRP is a very ancient particle closely related to ribosomes. Based on the significant increase of knowledge that has been accumulating on the structure of elongation factors and on their interactions with the ribosome, we speculate about a possible mechanism of the elongation arrest function.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Bui N,Strub Kdoi
10.1515/BC.1999.021keywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
135-45issue
2eissn
1431-6730issn
1437-4315journal_volume
380pub_type
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