Sphingomyelin breakdown in T cells: role in activation, effector functions and immunoregulation.

abstract：:Upon activation of the B cell antigen receptor (BCR), the spleen tyrosine kinase (Syk) and the Src family kinase Lyn phosphorylate tyrosines of the immunoreceptor tyrosine-based activation motif (ITAM) of Igα and Igβ which further serve as binding sites for the SH2 domains of these kinases. Using a synthetic biology a...

journal_title：Biological chemistry

authors： Kulathu Y,Zuern C,Yang J,Reth M

更新日期：2019-03-26 00:00:00

abstract：:Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Neuronal cell death due to oxidative stress may causally contribute to the pathogeneses of these diseases. Therefore, neuroprotective antioxida...

journal_title：Biological chemistry

authors： Moosmann B,Skutella T,Beyer K,Behl C

更新日期：2001-11-01 00:00:00

abstract：:The fundamental cellular role and molecular interactions of annexins in vesicle trafficking and membrane remodeling remain to be further clarified in order to better understand and exploit their contributions to health and disease. We focused on distinctive features of atypical annexins from all domains of life using ...

journal_title：Biological chemistry

authors： Fernandez MP,Garcia M,Martin-Almedina S,Morgan RO

更新日期：2017-06-27 00:00:00

abstract：:Hyperpolarization-activated cation currents, termed I(h), are observed in a variety of neurons. Four members of a gene family encoding hyperpolarization-activated cyclic-nucleotide-gated cation channels (HCN1-4) have been cloned. The regional expression and cellular localization of the four HCN channel types in mouse ...

journal_title：Biological chemistry

authors： Moosmang S,Biel M,Hofmann F,Ludwig A

更新日期：1999-07-01 00:00:00

abstract：:Many neurodegenerative disorders and syndromes are associated with an excessive generation of reactive oxygen species (ROS) and oxidative stress. The pathways to nerve cell death induced by diverse potential neurotoxins such as peptides, excitatory amino acids, cytokines or synthetic drugs commonly share oxidative dow...

journal_title：Biological chemistry

authors： Behl C,Moosmann B

更新日期：2002-03-01 00:00:00

abstract：:It is not rare that controversial indications about the presence or the expression level of multidrug-resistant (MDR) proteins come out from different laboratories upon examination of identical tumor specimens. Distinct aspects, including the use of weakly discriminating monoclonal antibodies (MAbs) and/or unsuitable ...

journal_title：Biological chemistry

authors： Poloni F,Castagna M,Felici F,Cianfriglia M

更新日期：1997-06-01 00:00:00

abstract：:We have previously described Kunitz-type serine proteinase inhibitors purified from Bauhinia seeds. Human plasma kallikrein shows different susceptibility to those inhibitors. In this communication, we describe the interaction of human plasma kallikrein with fluorogenic and non-fluorogenic peptides based on the Bauhin...

journal_title：Biological chemistry

authors： Oliva ML,Santomauro-Vaz EM,Andrade SA,Juliano MA,Pott VJ,Sampaio MU,Sampaio CA

更新日期：2001-01-01 00:00:00

abstract：:The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of cancers, including breast, prostate, and colorectal cancers. The dysregulation of metabolic pathways, including those involved in cholesterol biosynthesis, is ...

journal_title：Biological chemistry

authors： Murai T

更新日期：2015-01-01 00:00:00

abstract：:Fanconi anemia is a fatal, hereditary chromosome instability syndrome of early childhood with progressive pancytopenia and cancer-proneness. Hypersensitivity to alkylating agents points to DNA repair inefficiency. Excess reactive oxygen intermediates and hypersensitivity to oxygen, all features of Fanconi anemia cells...

journal_title：Biological chemistry

authors： Kontou M,Hirsch-Kauffmann M,Schweiger M

更新日期：2008-10-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization t...

journal_title：Biological chemistry

authors： Bernstein KE,Gonzalez-Villalobos RA,Giani JF,Shah K,Bernstein E,Janjulia T,Koronyo Y,Shi PD,Koronyo-Hamaoui M,Fuchs S,Shen XZ

更新日期：2014-10-01 00:00:00

abstract：:The primary cilium is a sensory organelle that is vital in regulating several signalling pathways. Unlike most organelles cilia are open to the rest of the cell, not enclosed by membranes. The distinct protein composition is crucial to the function of cilia and many signalling proteins and receptors are specifically c...

journal_title：Biological chemistry

authors： Stephen LA,Elmaghloob Y,Ismail S

更新日期：2017-12-20 00:00:00

abstract：:The O-acetylation of sialic acids turns out to be one of the most important modifications that influence the diverse biological and pathophysiological properties of glycoconjugates in animals and microorganisms. To understand the functions of this esterification, knowledge of the properties, structures and regulation ...

journal_title：Biological chemistry

authors： Iwersen M,Dora H,Kohla G,Gasa S,Schauer R

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this work was to study the regulative role of the glutamate receptor found earlier in the brain mitochondria. In the present work a glutamate-dependent signaling system with similar features was detected in mitochondria of the heart. The glutamate-dependent signaling system in the heart mitochondria was...

journal_title：Biological chemistry

authors： Selin AA,Lobysheva NV,Nesterov SV,Skorobogatova YA,Byvshev IM,Pavlik LL,Mikheeva IB,Moshkov DA,Yaguzhinsky LS,Nartsissov YR

更新日期：2016-05-01 00:00:00

abstract：:SlyD is a bacterial two-domain protein that functions as a molecular chaperone, a prolyl cis/trans isomerase, and a nickel-binding protein. This review summarizes recent findings about the molecular enzyme mechanism of SlyD. The chaperone function located in one domain of SlyD is involved in twin-arginine translocatio...

journal_title：Biological chemistry

authors： Kovermann M,Schmid FX,Balbach J

更新日期：2013-08-01 00:00:00

abstract：:Abstract Hairpin ribozymes occur naturally only in the satellite RNAs of tobacco ringspot virus (TRsV), chicory yellow mottle virus (CYMoV) and arabis mosaic virus (ArMV). The catalytic centre of the predominantly studied sTRsV hairpin ribozyme, and of sArMV is organised around a four-way helical junction. We show her...

journal_title：Biological chemistry

authors： Bajaj P,Steger G,Hammann C

更新日期：2011-07-01 00:00:00

abstract：:Thyroid hormones stimulate gap junctional communication in rat liver WB-F344 epithelial cells, elevating connexin43 mRNA and protein levels. In the present work we analysed connexin43 expression in liver and heart samples from thyroid hormone-treated Wistar rats. Connexin43 mRNA was elevated 2.1-fold in rat liver samp...

journal_title：Biological chemistry

authors： Stock A,Sies H

更新日期：2000-09-01 00:00:00

abstract：:Trypsin and chymotrypsin have similar tertiary structures, although very different substrate specificities. Trypsin hydrolyzes peptides at Lys/Arg residues while chymotrypsin recognizes large hydrophobic residues. Recent work has shown that trypsin is not converted into a protease with chymotrypsin-like activity when ...

journal_title：Biological chemistry

authors： Hedstrom L

更新日期：1996-07-01 00:00:00

abstract：:An inert polysaccharide scaffold identified as a 5-15% component of prion rods (PrP 27-30) is unambiguously distinguishable from the N-glycosyl groups and the GPI anchor of PrP, and consists predominantly of 1,4-linked glucose with some branching via 1,4,6-linked glucose. We show that this polysaccharide scaffold is a...

journal_title：Biological chemistry

authors： Dumpitak C,Beekes M,Weinmann N,Metzger S,Winklhofer KF,Tatzelt J,Riesner D

更新日期：2005-11-01 00:00:00

abstract：:The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene ...

journal_title：Biological chemistry

authors： Nishio H,Hamdi HK,Dugaiczyk A

更新日期：1999-12-01 00:00:00

abstract：:Myocardial zinc dyshomeostasis is associated with caspase-3 activation, ErbB2 degradation and apoptosis during hypoxia/reoxygenation. Zinc pyrithione replenishes intracellular zinc, suppresses caspase-3, augments ErbB2 levels and improves cell survival. We hypothesize that zinc is capable of modulating redox and endop...

journal_title：Biological chemistry

authors： Bodiga VL,Vemuri PK,Nimmagadda G,Bodiga S

更新日期：2020-10-25 00:00:00

abstract：:HB13 human myoblasts express physiological and biochemical markers associated with myoblast differentiation in non-human cell culture model systems. During differentiation, HB13 myoblasts also demonstrate fusion-related increases in cathepsin B activity and protein levels. These increases are associated with an increa...

journal_title：Biological chemistry

authors： Jane DT,Morvay LC,Koblinski J,Yan S,Saad FA,Sloane BF,Dufresne MJ

更新日期：2002-12-01 00:00:00

abstract：:In order to identify regulatory elements involved in the hepatocyte specific expression of the enzyme glutamine synthetase [GS (E.C. 6.3.1.2)] we analyzed the first intron of the rat GS gene. A sequence analysis detected clusters of potential transcription factor binding sites in regions that are hypersensitive for DN...

journal_title：Biological chemistry

authors： Gaunitz F,Gaunitz C,Papke M,Gebhardt R

更新日期：1997-01-01 00:00:00

abstract：:Eremophilanes are sesquiterpenes with a rearranged carbon skeleton formed both by plants and fungi, however, almost no plant eremophilanes are found in fungi. These eremophilanes possess mainly phytotoxic, antimicrobial, anticancer and immunomodulatory properties and in this review fungal eremophilanes with bioactivit...

journal_title：Biological chemistry

authors： Yuyama KT,Fortkamp D,Abraham WR

更新日期：2017-12-20 00:00:00

abstract：:The efficient execution of apoptotic cell death with the clearance of apoptotic debris by phagocytes is a key regulatory mechanism ensuring tissue homeostasis. Failure in this execution program contributes to the pathogenesis of many human diseases. In this review, we describe the current knowledge regarding the inter...

journal_title：Biological chemistry

authors： Weigert A,Jennewein C,Brüne B

更新日期：2009-05-01 00:00:00

abstract：:The Sialyl-Tn antigen (Sialyl alpha-Ser/Thr) is expressed as a cancer-associated antigen on the surface of cancer cells. Its presence is associated with a poor prognosis in patients with colorectal and other cancers. We previously reported that Sialyl-Tn expression in LSC human colon cancer cells could be explained by...

journal_title：Biological chemistry

authors： Brockhausen I,Yang J,Lehotay M,Ogata S,Itzkowitz S

更新日期：2001-02-01 00:00:00

abstract：:A novel antifungal protein, designated chrysancorin, was isolated from seeds of Chrysanthemum coronarium var. spatiosum with a procedure involving ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue resin, ion exchange chromatography on SP-Sepharose and FPLC-gel filtration on Superd...

journal_title：Biological chemistry

authors： Wang H,Ye XY,Ng TB

更新日期：2001-06-01 00:00:00

abstract：:Protein transport, especially into different cellular compartments, is a highly coordinated and regulated process. The molecular machineries which carry out these transport processes are highly complex in structure, function, and regulation. In the case of chloroplasts, thousands of protein molecules have been estimat...

journal_title：Biological chemistry

authors： Sommer MS,Schleiff E

更新日期：2009-08-01 00:00:00

abstract：:We have previously shown that short double-stranded RNAs of specific sequence induce phosphorylation in the activation loop of splicing variant D of the transforming growth factor beta-activated protein kinase 1 (TAK1-D). Here, we further characterize this novel function of TAK1-D and the mechanisms of this dsRNA-trig...

journal_title：Biological chemistry

authors： Kodym R,Kodym E,Story MD

更新日期：2009-05-01 00:00:00

abstract：:Disulfide bonds play a critical role in a variety of structural and mechanistic processes associated with proteins inside the cells and in the extracellular environment. The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfe...

journal_title：Biological chemistry

authors： Sousa SF,Neves RPP,Waheed SO,Fernandes PA,Ramos MJ

更新日期：2019-04-24 00:00:00

abstract：:In contrast to almost all other proteinases, human tissue-type plasminogen activator (tPA) is also proteolytically active in its zymogen or single-chain form. The closely related plasminogen activator isolated from vampire bat saliva (vPA) acts exclusively in the single-chain form, lacking the requisite cleavage site ...

journal_title：Biological chemistry

authors： Stubbs MT,Renatus M,Bode W

更新日期：1998-02-01 00:00:00