Abstract:
:The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of cancers, including breast, prostate, and colorectal cancers. The dysregulation of metabolic pathways, including those involved in cholesterol biosynthesis, is implicated in tumor development and cancer progression. Lipid rafts are highly dynamic cholesterol-enriched domains of the cell membrane, involved in various cellular functions, including the regulation of transmembrane signaling at the cell surface. It was recently demonstrated that lipid rafts also play critical roles in cancer cell adhesion and migration. This review focuses on our current understanding of how cholesterol regulation, lipid rafts, and dysregulated cholesterol biosynthesis contribute to cancer development and progression, and the therapeutic potential of cholesterol lowering for cancer prevention and treatment.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Murai Tdoi
10.1515/hsz-2014-0194subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-11issue
1eissn
1431-6730issn
1437-4315pii
/j/bchm.ahead-of-print/hsz-2014-0194/hsz-2014-0194journal_volume
396pub_type
杂志文章,评审abstract::Transforming growth factor-β (TGFβ) signaling acts as suppressor and inducer of tumor progression during the early and late stages of cancer, respectively. Some miRNAs have shown a regulatory effect on TGFβ signaling and here, we have used a combination of bioinformatics and experimental tools to show that hsa-miR-559...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2018-0264
更新日期:2019-04-24 00:00:00
abstract::Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue. The human T-SP1 gene encompasses 28.7 kb on the short arm of chromosome 8 and consists of seven exons. Rapid amplificatio...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.170
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abstract::RIO1 is an essential gene that encodes a protein serine kinase and is transcribed constitutively at a very low level. Transcriptional activation of RIO1 dispenses with a canonical TATA box as well as with classical transactivators or specific DNA-binding factors. Instead, a dG-dC-rich sequence element, that is located...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2003.143
更新日期:2003-09-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2007.083
更新日期:2007-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.159
更新日期:2001-08-01 00:00:00
abstract::Many aspects of the RNA maturation leave traces in RNA sequencing data in the form of deviations from the reference genomic DNA. This includes, in particular, genomically non-encoded nucleotides and chemical modifications. The latter leave their signatures in the form of mismatches and conspicuous patterns of sequenci...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2011.043
更新日期:2011-04-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/hsz-2020-0286
更新日期:2020-10-22 00:00:00
abstract::Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 1...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.085
更新日期:2008-06-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2019-03-26 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2006.004
更新日期:2006-01-01 00:00:00
abstract::Ammonia is a major player in the pathogenesis of hepatic encephalopathy (HE) and affects astrocyte function by triggering a self-amplifying cycle between osmotic and oxidative stress. We recently demonstrated that hypoosmotic astrocyte swelling rapidly stimulates nitric oxide (NO) production and increases intracellula...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2011.199
更新日期:2011-12-01 00:00:00
abstract::N-acyl homoserine lactones (AHLs) are quorum sensing (QS) signal molecules used by most Gram-negative pathogenic bacteria. In this article the lactonase activity of the preparations based on hexahistidine-tagged organophosphorus hydrolase (His6-OPH) towards AHLs was studied. Initially, three of the most interesting β-...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2018-0162
更新日期:2018-07-26 00:00:00
abstract::We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of α5/β1/αv/β3 integrin expression. We al...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2017-0339
更新日期:2018-09-25 00:00:00
abstract::We present a rapid and simple method for the sexing of human and other primate DNA. Homologous introns from the X- and Y-linked zinc finger protein genes (ZFX and ZFY) are PCR amplified with one primer pair. An Alu element insertion in the ZFX intron results in a size difference in the amplicons which is resolved by a...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::Hyperpolarization-activated cation currents, termed I(h), are observed in a variety of neurons. Four members of a gene family encoding hyperpolarization-activated cyclic-nucleotide-gated cation channels (HCN1-4) have been cloned. The regional expression and cellular localization of the four HCN channel types in mouse ...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.1999.121
更新日期:1999-07-01 00:00:00
abstract::The lysosomal cysteine proteases cathepsin B and L play important roles in tumor cell invasion. An imbalance between these cathepsins and their endogenous inhibitors, the cystatins, has been associated with development of the metastatic phenotype. Accordingly, many studies have indicated potential use of cystatins in ...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.035
更新日期:2008-04-01 00:00:00
abstract::To exploit the B-lymphocyte antigen-CD20 binding capacity of the Ibritumomab tiuxetan (IBTN) monoclonal antibody (mAb) for imaging, the over-expression of B cells in non-Hodgkin's lymphoma (NHL) (a myeloproliferative disorder of the lymphatic system) was investigated. In the current investigation, we present the label...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC-2011-170
更新日期:2012-01-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization t...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/hsz-2013-0295
更新日期:2014-10-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.1999.021
更新日期:1999-02-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2009.070
更新日期:2009-07-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2016-0119
更新日期:2017-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::Meprins are zinc-endopeptidases of the astacin family, which are expressed as membrane-bound or secreted forms in renal and intestinal brush-border membranes of mouse, rat and man. There are two types of meprin subunits, alpha and beta, which form disulfide-bonded homo- and heterodimers; further oligomerization is med...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2003.092
更新日期:2003-05-01 00:00:00
abstract::Dipeptidyl peptidase-IV has been demonstrated to play a role in cancer biology by many authors. Since then, additional proteins possessing similar enzymatic activity have been described and their role in cancerogenesis has been hypothesized. To assess the complexity of these 'Dipeptidyl peptidase-IV activity and/or st...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2004.067
更新日期:2004-06-01 00:00:00
abstract::N.BstNBI is a unique restriction endonuclease isolated from Bacillus stearothermophilus. We have characterized the recognition sequence and the cleavage site of N.BstNBI. Mapping of cleavage sites of N.BstNBI showed that it recognizes an asymmetric sequence, 5' GAGTC 3', and cleaves only on the top strand 4 base pairs...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2000.137
更新日期:2000-11-01 00:00:00
abstract::The transcription factor GLI1 is one of three vertebrate members of the GLI family, which is characterized by a highly conserved DNA-binding domain of five zinc fingers. We have analyzed whether human GLI1 is a target of PKA regulation. It was found that PKA inhibits GLI1 transcriptional activity. However, no evidence...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2000.070
更新日期:2000-07-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2005.080
更新日期:2005-07-01 00:00:00
abstract::The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2008.010
更新日期:2008-01-01 00:00:00