Abstract:
:We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of α5/β1/αv/β3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Haddada M,Draoui H,Deschamps L,Walker F,Delaunay T,Brattsand M,Magdolen V,Darmoul Ddoi
10.1515/hsz-2017-0339subject
Has Abstractpub_date
2018-09-25 00:00:00pages
1099-1105issue
9eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2017-0339/hsz-2017-0339.journal_volume
399pub_type
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