The pathobiochemistry of nitrogen dioxide.

Abstract:

:Nitrogen dioxide (*NO2) is an oxidizing free radical which can initiate a variety of destructive pathways in living systems, and several diseases are suspected to be connected with both exogenously and endogenously formed *NO2. Peroxynitrite (ONOO-/ONOOH) is believed to be an important endogenous source of *NO2 radicals, but other sources, among them enzymatically ones, have been identified recently. It also became clear during the last few years that in vivo formation of 3-nitrotyrosine strictly depends on the availability of *NO2 radicals. Since nitrogen dioxide is a very toxic compound an arsenal of antioxidants (e.g. vitamin C, glutathione, vitamin E, and beta-carotene) must eliminate this harmful radical in vivo. Here the recently identified superoxide (O2*-)-dependent formation of peroxynitrate (O2NOO-) and the central role of vitamin C are of special importance.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Kirsch M,Korth HG,Sustmann R,de Groot H

doi

10.1515/BC.2002.043

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

389-99

issue

3-4

eissn

1431-6730

issn

1437-4315

journal_volume

383

pub_type

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