Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes.

Abstract:

:The kinin B2 receptor, which is constitutively expressed in a large number of tissues, mediates most of the known effects of bradykinin (BK). Normally undetectable in healthy tissues, the B1 receptor is strongly over-expressed under pathological conditions. BK is an important mediator in renal homeostasis and is mainly known for its natriuretic and vasodilatory effects. Recent data evidenced a role for BK in many other biological processes, such as apoptosis, development, extracellular matrix regulation and angiogenesis. In a first step to better understand how BK and its receptors could be involved in such a large variety of biological effects, we used microarray analysis to identify, under physiological conditions, the global renal gene expression profile in mice lacking either the kinin B1 or B2 receptor. Microarray experiments were performed using Agilent Mouse Oligonucleotide Microarrays (21,000 genes/microarray). Interestingly, there was a considerable number of mostly downregulated genes in both BK null mouse models compared with wild-type mice. Furthermore, a number of genes that are known to be implicated in renal physiology and/or pathology were differentially expressed in the BK null mice, which is indicative of the important role of both BK receptors in renal function.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Bachvarov D,Bachvarova M,Koumangaye R,Klein J,Pesquero JB,Neau E,Bader M,Schanstra JP,Bascands JL

doi

10.1515/BC.2006.004

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

15-22

issue

1

eissn

1431-6730

issn

1437-4315

journal_volume

387

pub_type

杂志文章
  • Shining light on plant hormones with genetically encoded biosensors.

    abstract::Signalling molecules are produced, degraded, modified and transported throughout the development of higher organisms. Understanding their mode of action implies understanding these dynamics in vivo and in real time. Genetically encoded biosensors are being more and more used as tools to 'follow' signalling molecules a...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2018-0310

    authors: Martin-Arevalillo R,Vernoux T

    更新日期:2019-03-26 00:00:00

  • Hsp70 chaperone systems: diversity of cellular functions and mechanism of action.

    abstract::Hsp70 chaperone systems play an essential role in the life cycle of many proteins not only in an hostile environment but also under normal growth conditions. In the course of evolution the diversification of functions was accompanied by an amplification of components of the Hsp70 system. Here strategies are reviewed h...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Mayer MP,Bukau B

    更新日期:1998-03-01 00:00:00

  • Cell traces--footprints of individual cells during locomotion and adhesion.

    abstract::Animal cells release traces of material onto glass or silicon surfaces during adhesion and migration. This little studied phenomenon is a widespread and normal concomitant of cell migration. The paper introduces the study of such material. The traces can be visualised by different microscopic techniques (e.g. TIRF, IR...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1998.379.8-9.1161

    authors: Fuhr G,Richter E,Zimmermann H,Hitzler H,Niehus H,Hagedorn R

    更新日期:1998-08-01 00:00:00

  • Comparative study of the differential cell death protecting effect of various ROS scavengers.

    abstract::Oxidative stress has for a long time been associated with cell death, especially classical necrosis, however, its role in other cell death pathways is less clear. Here, we evaluated in a comparative way, the effect of four different reactive oxygen species (ROS) scavengers, N-acetyl-L-cysteine (NAC), α-tocopherol and ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0317

    authors: Kavčič N,Pegan K,Vandenabeele P,Turk B

    更新日期:2019-01-28 00:00:00

  • Cellular expression of plasma prekallikrein in human tissues.

    abstract::Plasma prekallikrein (PPK) is synthesised in hepatocytes and secreted into the blood, where it participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. Recently we demonstrated by quantitative RT-PCR that the human PPK gene is transcribed not only in the l...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.104

    authors: Fink E,Bhoola KD,Snyman C,Neth P,Figueroa CD

    更新日期:2007-09-01 00:00:00

  • C-terminal peptides of interleukin-6 modulate the expression of junB protooncogene and the production of fibrinogen by HepG2 cells.

    abstract::Interleukin-6 (IL-6) is a 185 amino acid residue helical cytokine with various biological activities (e. g. B cell development, acute phase reaction). We have investigated the role of the 168-185 C-terminal region of IL-6 in the induction of fibrinogen synthesis and expression of junB mRNA using synthetic peptides cor...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2001.079

    authors: Igaz P,Bösze S,Tóth S,Falus A,Hudecz F

    更新日期:2001-04-01 00:00:00

  • Zinc networks: the cell-specific compartmentalization of zinc for specialized functions.

    abstract::Zinc (Zn2+) is the most abundant trace element in cells and is essential for a vast number of catalytic, structural, and regulatory processes. Mounting evidence indicates that like calcium (Ca2+), intracellular Zn2+ pools are redistributed for specific cellular functions. This occurs through the regulation of 24 Zn2+ ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2012-0128

    authors: Hennigar SR,Kelleher SL

    更新日期:2012-07-01 00:00:00

  • Substrate specificity of glutaminyl cyclases from plants and animals.

    abstract::Glutaminyl cyclases (QC) catalyze the intramolecular cyclization of N-terminal glutamine residues of peptides and proteins. For a comparison of the substrate specificity of human and papaya QC enzymes, a novel continuous assay was established by adapting an existing discontinuous method. Specificity constants (kcat/Km...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2003.175

    authors: Schilling S,Manhart S,Hoffmann T,Ludwig HH,Wasternack C,Demuth HU

    更新日期:2003-12-01 00:00:00

  • Compatible organic osmolytes and osmotic modulation of inducible nitric oxide synthetase in RAW 264.7 mouse macrophages.

    abstract::The influence of osmolarity and compatible organic osmolytes on the phosphorylation of the MAP-kinases Erk-1 and Erk-2 and on the expression of taurine transporter (TAUT) and lipopolysaccharide (LPS)-induced nitric oxide synthetase (iNOS) was studied in RAW 264.7 mouse macrophages. Hypoosmolarity (205 mosmol/l) but no...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1998.379.7.867

    authors: Warskulat U,Schliess F,Häussinger D

    更新日期:1998-07-01 00:00:00

  • Mg2+ homeostasis and transport in cyanobacteria - at the crossroads of bacterial and chloroplast Mg2+ import.

    abstract::Magnesium cation (Mg2+) is the most abundant divalent cation in living cells, where it is required for various intracellular functions. In chloroplasts and cyanobacteria, established photosynthetic model systems, Mg2+ is the central ion in chlorophylls, and Mg2+ flux across the thylakoid membrane is required for count...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2018-0476

    authors: Pohland AC,Schneider D

    更新日期:2019-09-25 00:00:00

  • Sphingomyelin breakdown in T cells: role in activation, effector functions and immunoregulation.

    abstract::Host T cell activation, a key step in obtaining adaptive immunity against pathogens, is initiated by the binding of the T cell receptor to a foreign antigenic peptide presented by the major histocompatibility complex on the surface of an antigen-presenting cell and, consequently, formation of an immunological synapse....

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2014-0282

    authors: Beyersdorf N,Müller N

    更新日期:2015-06-01 00:00:00

  • The magnetofection method: using magnetic force to enhance gene delivery.

    abstract::In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical ...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2003.082

    authors: Plank C,Schillinger U,Scherer F,Bergemann C,Rémy JS,Krötz F,Anton M,Lausier J,Rosenecker J

    更新日期:2003-05-01 00:00:00

  • Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells.

    abstract::The p53 tumour suppressor gene is frequently mutated in human tumours and different tumour-derived mutations have varying effects on cells. The effect of a novel tumour-derived p53 mutation and two recently described mutations from South African breast cancer patients on the growth rate, colony formation, cell cycle a...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2008.010

    authors: Donninger H,Binder A,Bohm L,Parker MI

    更新日期:2008-01-01 00:00:00

  • Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy.

    abstract::The neurobiological mechanisms of obesity-induced peripheral neuropathy are poorly understood. We evaluated the role of Sigma-1 receptor (Sig-1R) and NMDA receptor (NMDARs) in the spinal cord in peripheral neuropathy using an animal model of high fat diet-induced diabetes. We examined the expression of Sig-1R and NMDA...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0117

    authors: Song T,Zhao J,Ma X,Zhang Z,Jiang B,Yang Y

    更新日期:2017-09-26 00:00:00

  • Full length cDNA of rat RT1.DMa and RT1.DMb and expression of RT1.DM genes in dendritic and Langerhans cells.

    abstract::MHC encoded DM heterodimers and classical MHC class II complexes meet in an endosomal/lysosomal compartment where DM heterodimers support peptide loading of MHC class II. Studies on peptide loading of rat class II and on peptide persistence in cells of the dendritic lineage prompted us to establish full length cDNA cl...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm.1997.378.9.1005

    authors: Kurth D,Neumann J,Demleitner K,Hildmann J,Mehlig M,Scheicher C,Wendling U,Sun D,Reske K

    更新日期:1997-09-01 00:00:00

  • Epigallocatechin gallate inhibits endothelial exocytosis.

    abstract::Consumption of green tea is associated with a decrease in cardiovascular mortality. The beneficial health effects of green tea are attributed in part to polyphenols, organic compounds found in tea that lower blood pressure, reduce body fat, decrease LDL cholesterol, and inhibit inflammation. We hypothesized that epiga...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2008.095

    authors: Yamakuchi M,Bao C,Ferlito M,Lowenstein CJ

    更新日期:2008-07-01 00:00:00

  • A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells.

    abstract::Nanoparticles (NPs) are recognized as an attractive vehicles for cancer treatment due to their targeted drug release. Gastric cancer is an important killer disease, and its therapy methods still need improvement. The NPs were prepared using a precipitation method, and were evaluated using transmission electron microsc...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2017-0208

    authors: Yang W,Zhang H,Xin L

    更新日期:2018-02-23 00:00:00

  • IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.

    abstract::The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the insulin-like growth factor (IGF) system, a well-known activator ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2012-0209

    authors: Kraus S,Fruth M,Bunsen T,Nägler DK

    更新日期:2012-12-01 00:00:00

  • Activation of progelatinase A by mammalian legumain, a recently discovered cysteine proteinase.

    abstract::The activation of progelatinase A to gelatinase A requires cleavage of an asparaginyl bond to form the N-terminus of the mature enzyme. We have asked whether the activation can be mediated by legumain, the recently discovered lysosomal cysteine proteinase that is specific for hydrolysis of asparaginyl bonds. Addition ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2001.093

    authors: Chen JM,Fortunato M,Stevens RA,Barrett AJ

    更新日期:2001-05-01 00:00:00

  • Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase from Pseudomonas aeruginosa.

    abstract::Arginine deiminase (ADI) is a potential antitumor agent for the arginine deprivation treatment of L-arginine auxotrophic tumors. The optimum pH of ADI varies significantly, yet little is known about the origin of this variety. Here, Pseudomonas aeruginosa ADI (PaADI), an enzyme that functions only at acidic pH, was ut...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/hsz-2012-0183

    authors: Ding H,Liu H,Yin Y,Ding Y,Jia Y,Chen Q,Zou G,Zheng Z

    更新日期:2012-09-01 00:00:00

  • Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases.

    abstract::Plasma kallikrein plays a role in coagulation, fibrinolysis and inflammation. Cathepsins B and L participate in (patho)physiological processes such as peptide antigen processing, tissue remodeling events, protein turnover in cells, hormone processing and tumor invasion. The present work analyzes the processing of prek...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2004.141

    authors: Barros NM,Puzer L,Tersariol IL,Oliva ML,Sampaio CA,Carmona AK,Motta G

    更新日期:2004-11-01 00:00:00

  • Impaired synthesis of heme oxygenase-1 in Fanconi anemia cells can be rescued by transfection of Fanconi wild-type cDNA.

    abstract::Fanconi anemia is a fatal, hereditary chromosome instability syndrome of early childhood with progressive pancytopenia and cancer-proneness. Hypersensitivity to alkylating agents points to DNA repair inefficiency. Excess reactive oxygen intermediates and hypersensitivity to oxygen, all features of Fanconi anemia cells...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2008.151

    authors: Kontou M,Hirsch-Kauffmann M,Schweiger M

    更新日期:2008-10-01 00:00:00

  • Expression, subcellular distribution and plasma membrane binding of cathepsin B and gelatinases in bone metastatic tissue.

    abstract::The possible application of proteinase inhibitors in the support of anti-tumor chemotherapy requires profound knowledge of the proteinases involved in malignant processes. Therefore, the occurrence of cathepsins B, D, H, L and S and of gelatinases, urokinase plasminogen activator and stromelysins was studied in biopsi...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/bchm3.1996.377.11.695

    authors: Arkona C,Wiederanders B

    更新日期:1996-11-01 00:00:00

  • Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.

    abstract::The cellular adhesion molecule E-selectin is expressed on activated endothelial cells, and is involved in the process of adherence of blood cells to vessel endothelium in inflammatory events such as atherosclerosis. In a recent study we found a Ser128Arg mutation in the EGF domain as well as a Leu554Phe mutation in th...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.1999.082

    authors: Wenzel K,Stahn R,Speer A,Denner K,Gläser C,Affeldt M,Moobed M,Scheer A,Baumann G,Felix SB

    更新日期:1999-06-01 00:00:00

  • Glycine-assisted enhancement of 1,4-beta-d-xylan xylanohydrolase activity at alkaline pH with a pH optimum shift.

    abstract::This is the first report describing the enhancement of xylanase activity by the neutral amino acid glycine. Xylanase activity is increased seven-fold at alkaline pH in the presence of glycine and its pH optimum is shifted from pH 7 to 8 without using any protein engineering techniques. Analysis of the steady-state kin...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2007.007

    authors: Vathipadiekal V,Verma A,Rao M

    更新日期:2007-01-01 00:00:00

  • Emerging mechanisms of drug-induced phospholipidosis.

    abstract::Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of phospholipids. Its cellular mechanism is still not well understood, but it is known that cationic amphiphilic drugs can induce it. These drugs have a hydrophilic amine head group that can be protonated in the endol...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2019-0270

    authors: Breiden B,Sandhoff K

    更新日期:2019-12-18 00:00:00

  • Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner.

    abstract::While the role of C2-ceramide in the induction of programmed cell death (PCD) in animal systems has been well documented, little is known of its role in plant cells. Here we show that C2-ceramide induces PCD in Arabidopsis suspension cultures, which is preceded by the generation of a calcium transient and an increase ...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2005.020

    authors: Townley HE,McDonald K,Jenkins GI,Knight MR,Leaver CJ

    更新日期:2005-02-01 00:00:00

  • Chaperone-assisted degradation: multiple paths to destruction.

    abstract::Molecular chaperones are well known as facilitators of protein folding and assembly. However, in recent years multiple chaperone-assisted degradation pathways have also emerged, including CAP (chaperone-assisted proteasomal degradation), CASA (chaperone-assisted selective autophagy), and CMA (chaperone-mediated autoph...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/BC.2010.058

    authors: Kettern N,Dreiseidler M,Tawo R,Höhfeld J

    更新日期:2010-05-01 00:00:00

  • Contribution of astrocytes to metabolic dysfunction in the Alzheimer's disease brain.

    abstract::Historically considered as accessory cells to neurons, there is an increasing interest in the role of astrocytes in normal and pathological conditions. Astrocytes are involved in neurotransmitter recycling, antioxidant supply, ion buffering and neuroinflammation, i.e. a lot of the same pathways that go astray in Alzhe...

    journal_title:Biological chemistry

    pub_type: 杂志文章,评审

    doi:10.1515/hsz-2019-0140

    authors: Zulfiqar S,Garg P,Nieweg K

    更新日期:2019-08-27 00:00:00

  • Association of betaine-homocysteine S-methyltransferase with microtubules.

    abstract::In mammals, betaine of the mitochondrial matrix is used in the cytosol by betaine-homocysteine S-methyltransferase for methionine synthesis. The resulting dimethylglycine is shuttled back into the mitochondrial matrix for further degradation. Nanospray tandem mass spectrometry and N-terminal amino acid sequencing of m...

    journal_title:Biological chemistry

    pub_type: 杂志文章

    doi:10.1515/BC.2000.080

    authors: Sandu C,Nick P,Hess D,Schiltz E,Garrow TA,Brandsch R

    更新日期:2000-07-01 00:00:00