Abstract:
:Metarhizium anisopliae is an entomopathogenic fungus relevant in biotechnology with applications like malaria vector control. Studies of its virulence factors are therefore of great interest. Fungal ribotoxins are toxic ribonucleases with extraordinary efficiency against ribosomes and suggested as potential insecticides. Here we describe this ribotoxin characteristic activity in M. anisopliae cultures. Anisoplin has been obtained as a recombinant protein and further characterized. It is structurally similar to hirsutellin A, the ribotoxin from the entomopathogen Hirsutella thompsonii. Moreover, anisoplin shows the ribonucleolytic activity typical of ribotoxins and cytotoxicity against insect cells. How Metarhizium uses this toxin and possible applications are of interest.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Olombrada M,Medina P,Budia F,Gavilanes JG,Martínez-Del-Pozo Á,García-Ortega Ldoi
10.1515/hsz-2016-0119subject
Has Abstractpub_date
2017-01-01 00:00:00pages
135-142issue
1eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2016-0119/hsz-2016-0119.journal_volume
398pub_type
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