Abstract:
:Dipeptidyl peptidase-IV has been demonstrated to play a role in cancer biology by many authors. Since then, additional proteins possessing similar enzymatic activity have been described and their role in cancerogenesis has been hypothesized. To assess the complexity of these 'Dipeptidyl peptidase-IV activity and/or structure homologs' (DASH) in glioma cells, we have studied their presence in cell lines of different degree of transformation. Our results provide evidence of cell line-specific expression and distribution of dipeptidyl peptidase-IV enzyme activity-bearing molecules and their dynamics associated with cell growth conditions. The biologic outcome of DASH pattern of composition probably depends on the regulatory peptides/DASH substrates in the cellular environment.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Sedo A,Busek P,Scholzová E,Malík R,Vlasicová K,Janácková S,Mares Vdoi
10.1515/BC.2004.067keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
557-9issue
6eissn
1431-6730issn
1437-4315journal_volume
385pub_type
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