Abstract:
:Cysteine proteases of the malaria parasite Plasmodium falciparum, known as falcipains, are promising targets for antimalarial chemotherapy. We evaluated cultured parasites for the stage-specific expression of cysteine proteases and sensitivity to cysteine protease inhibitors. Protease activity and inhibitor sensitivity varied markedly over time. Cysteine protease activity was greatest in early trophozoites, while sensitivity to cysteine protease inhibitors was greatest in mature trophozoites. Our results indicate the importance of considering the stage-specific effects of antimalarials and are consistent with the conclusion that the principal antimalarial activity of cysteine protease inhibitors is due to a block in hemoglobin hydrolysis.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Shenai BR,Semenov AV,Rosenthal PJdoi
10.1515/BC.2002.089keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
843-7issue
5eissn
1431-6730issn
1437-4315journal_volume
383pub_type
杂志文章abstract::Parvulins belong to the family of peptidyl-prolyl cis/trans isomerases (PPIases) assisting in protein folding and in regulating the function of a broad variety of proteins in all branches of life. The human representatives Pin1 and Par14/17 are directly involved in processes influencing cellular maintenance and cell f...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/hsz-2017-0137
更新日期:2018-01-26 00:00:00
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journal_title:Biological chemistry
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journal_title:Biological chemistry
pub_type: 杂志文章
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Biological chemistry
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更新日期:2002-03-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-06-26 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.029
更新日期:2001-02-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2014-0277
更新日期:2015-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2003.153
更新日期:2003-10-01 00:00:00
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.1999.129
更新日期:1999-09-01 00:00:00
abstract::The amyloid precursor protein (APP) and its processing are widely believed to be central for the etiology of Alzheimer's disease (AD) and appear essential for neuronal development and cell homeostasis in mammals. Many studies show the proteolysis of APP by the proteases α-, β- and γ-secretase, functional aspects of th...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
abstract::Two members of the nuclear receptor superfamily, EcR (ecdysteroid receptor protein) and Usp (Ultraspiracle), heterodimerize to form a functional receptor for the steroid hormone 20-hydroxyecdysone and thus enable it to coordinate morphogenetic events during insect metamorphosis. N-terminally His-tagged Usp was overexp...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract::The ubiquitous calpains, mu- and m-calpain, have been implicated in essential physiological processes and various pathologies. Cell-permeable specific inhibitors are important tools to elucidate the roles of calpains in cultivated cells and animal models. The synthetic N-acetylated 27-mer peptide derived from exon B o...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Biological chemistry
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更新日期:2009-08-01 00:00:00
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journal_title:Biological chemistry
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更新日期:2001-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
abstract::Dog pancreas microsomes represent the key components of the established model system for the analysis of protein transport into the mammalian endoplasmic reticulum. More recently, these microsomes were also employed in cell-free systems which address questions related to protein folding and protein degradation in the ...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.1999.149
更新日期:1999-10-01 00:00:00