Genomic expansion across the albumin gene family on human chromosome 4q is directional.

Abstract:

:The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene family. These repetitive motifs provide an internal reference, allowing observations of evolutionary changes within a single line (human) of evolutionary descent. The four genes and three intergenic regions between them increase in size as they get closer to the centromere. An invasion by multiple repetitive DNA elements may account, in part, for this expansion.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Nishio H,Hamdi HK,Dugaiczyk A

doi

10.1515/BC.1999.183

keywords:

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1431-4

issue

12

eissn

1431-6730

issn

1437-4315

journal_volume

380

pub_type

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