Abstract:
:The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene family. These repetitive motifs provide an internal reference, allowing observations of evolutionary changes within a single line (human) of evolutionary descent. The four genes and three intergenic regions between them increase in size as they get closer to the centromere. An invasion by multiple repetitive DNA elements may account, in part, for this expansion.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Nishio H,Hamdi HK,Dugaiczyk Adoi
10.1515/BC.1999.183keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1431-4issue
12eissn
1431-6730issn
1437-4315journal_volume
380pub_type
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