Abstract:
:Eukaryotic organisms have evolved complex and robust cellular stress response pathways to ensure maintenance of proteostasis and survival during fluctuating environmental conditions. Highly conserved stress response pathways can be triggered and coordinated at the cell-autonomous and cell-nonautonomous level by proteostasis transcription factors, including HSF1, SKN-1/NRF2, HIF1, and DAF-16/FOXO that combat proteotoxic stress caused by environmental challenges. While these transcription factors are often associated with a specific stress condition, they also direct "noncanonical" transcriptional programs that serve to integrate a multitude of physiological responses required for development, metabolism, and defense responses to pathogen infections. In this review, we outline the established function of these key proteostasis transcription factors at the cell-autonomous and cell-nonautonomous level and discuss a newly emerging stress responsive transcription factor, PQM-1, within the proteostasis network. We look beyond the canonical stress response roles of proteostasis transcription factors and highlight their function in integrating different physiological stimuli to maintain cytosolic organismal proteostasis.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Jones LM,Chen Y,van Oosten-Hawle Pdoi
10.1515/hsz-2019-0385subject
Has Abstractpub_date
2020-08-27 00:00:00pages
1005-1018issue
9eissn
1431-6730issn
1437-4315pii
/j/bchm.just-accepted/hsz-2019-0385/hsz-2019-0385.journal_volume
401pub_type
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