Abstract:
:Only one transcript for KLK10 was identified by RT-PCR in lung tissue, whereas KLK11 expressed at least four alternative transcripts. Quantitative analysis of KLK10 and KLK11 expression levels was assessed by real-time PCR, in a cohort of 47 patients with non-small-cell lung cancer (NSCLC). Expression levels of these genes were widely distributed in the population studied. Multivariate analysis revealed a correlation between KLK10 over-expression and the squamous cell carcinoma histotype (p=0.034). There was no correlation between gene expression and patient survival. Overall, both genes behaved similarly (p<0.001). These results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in NSCLC. Finally, our findings indicate that these genes are likely involved in normal physiology processes in bronchus.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Planque C,Aïnciburu M,Heuzé-Vourc'h N,Régina S,de Monte M,Courty Ydoi
10.1515/BC.2006.098subject
Has Abstractpub_date
2006-06-01 00:00:00pages
783-8issue
6eissn
1431-6730issn
1437-4315journal_volume
387pub_type
杂志文章abstract::MHC (major histocompatibility complex) class I molecules bind intracellular virus-derived peptides in the endoplasmic reticulum (ER) and present them at the cell surface to cytotoxic T lymphocytes. Peptide-free class I molecules at the cell surface, however, could lead to aberrant T cell killing. Therefore, cells ensu...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2004.100
更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-11-27 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Biological chemistry
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pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-20 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2004.001
更新日期:2004-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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更新日期:2005-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-11-26 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/bchm.1997.378.3-4.265
更新日期:1997-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1515/bchm.1998.379.4-5.401
更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.1999.159
更新日期:1999-10-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2005.088
更新日期:2005-08-01 00:00:00