The eukaryotic gene transcription machinery.

Abstract:

:Seven purified proteins may be combined to reconstitute regulated, promoter-dependent RNA polymerase II transcription: five general transcription factors, Mediator, and RNA polymerase II. The entire system has been conserved across species from yeast to humans. The structure of RNA polymerase II, consisting of 10 polypeptides with a mass of about 500 kDa, has been determined at atomic resolution. On the basis of this structure, that of an actively transcribing RNA polymerase II complex has been determined as well.

journal_name

Biol Chem

journal_title

Biological chemistry

authors

Kornberg RD

doi

10.1515/BC.2001.140

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

1103-7

issue

8

eissn

1431-6730

issn

1437-4315

journal_volume

382

pub_type

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