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BRAF inhibitor unveils its potential against advanced melanoma.

Abstract：

:Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 that validate oncogene-targeted melanoma therapy.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Vultur A,Villanueva J,Herlyn M

doi

10.1016/j.ccr.2010.10.001

subject

Has Abstract

pub_date

2010-10-19 00:00:00

pages

301-2

issue

4

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(10)00347-8

journal_volume

18

pub_type

评论,杂志文章

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