Abstract：
:It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2 transgenic glands displayed disseminated tumor cells and micrometastasis in bone marrow and lungs. The number of disseminated cancer cells and their karyotypic abnormalities were similar for small and large tumors in patients and mouse models. When activated by bone marrow transplantation into wild-type recipients, 80 early-disseminated cancer cells sufficed to induce lethal carcinosis. Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Hüsemann Y,Geigl JB,Schubert F,Musiani P,Meyer M,Burghart E,Forni G,Eils R,Fehm T,Riethmüller G,Klein CAdoi
10.1016/j.ccr.2007.12.003subject
Has Abstractpub_date
2008-01-01 00:00:00pages
58-68issue
1eissn
1535-6108issn
1878-3686pii
S1535-6108(07)00372-8journal_volume
13pub_type
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