Abstract:
:In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Naylor RM,van Deursen JMdoi
10.1016/j.ccell.2017.01.011subject
Has Abstractpub_date
2017-02-13 00:00:00pages
165-166issue
2eissn
1535-6108issn
1878-3686pii
S1535-6108(17)30011-9journal_volume
31pub_type
评论,杂志文章相关文献
CANCER CELL文献大全abstract::Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transformation, the consequences of Tet2 loss in hematopoietic development have not b...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.06.001
更新日期:2011-07-12 00:00:00
abstract::Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, a...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2020.03.008
更新日期:2020-04-13 00:00:00
abstract::In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 statu...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.04.010
更新日期:2016-05-09 00:00:00
abstract::The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.08.012
更新日期:2007-09-01 00:00:00
abstract::Hepatocyte I kappaB kinase beta (IKK beta) inhibits hepatocarcinogenesis by suppressing accumulation of reactive oxygen species (ROS) and liver damage, whereas JNK1 activation promotes ROS accumulation, liver damage, and carcinogenesis. We examined whether hepatocyte p38 alpha, found to inhibit liver carcinogenesis, a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.06.016
更新日期:2008-08-12 00:00:00
abstract::The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, Fc-FcγR interactions have been shown to be important for mAb-directed effector ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.05.005
更新日期:2018-06-11 00:00:00
abstract::In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.07.003
更新日期:2020-08-10 00:00:00
abstract::In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B ove...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.10.011
更新日期:2018-11-12 00:00:00
abstract::Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50% (22 of 44) of resistant BCCs and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. Alterations include four ligand ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.02.002
更新日期:2015-03-09 00:00:00
abstract::Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.08.014
更新日期:2016-09-12 00:00:00
abstract::During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.06.018
更新日期:2009-08-04 00:00:00
abstract::The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) a...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00102-2
更新日期:2002-08-01 00:00:00
abstract::The nervous system is emerging as a regulator of malignancy. In this issue of Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve growth factor promotes enteric tumor innervation, and recruited nerves drive cancer growth through acetylcholine-regulated Wnt signaling and s...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.12.008
更新日期:2017-01-09 00:00:00
abstract::The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT-medulloblastoma, an essentially curable form of the disease, induce an aberrant fenestrated vasculature that permits the accumulation of high levels o...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.03.002
更新日期:2016-04-11 00:00:00
abstract::The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.10.003
更新日期:2015-12-14 00:00:00
abstract::The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid tumors. However, there are no guidelines for optimal scheduling of these therapies. Here we show that VEGFR2 blockade creates a "normalizati...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.10.011
更新日期:2004-12-01 00:00:00
abstract::Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.11.012
更新日期:2018-12-10 00:00:00
abstract::Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblasto...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.09.014
更新日期:2014-11-10 00:00:00
abstract::We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells. Such compounds included quaternary ammo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.01.012
更新日期:2006-02-01 00:00:00
abstract::Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine counterparts. However, a precise enumeration of these differences has never been undertaken. We have determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tu...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.07.009
更新日期:2004-08-01 00:00:00
abstract::Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of grow...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.08.004
更新日期:2012-09-11 00:00:00
abstract::The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is associated with increased risk of juvenile myelomonocytic leukemia (JMML). Somatic Shp2 mutations occur in sporadic JMML and other leukemias. We found...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.01.010
更新日期:2005-02-01 00:00:00
abstract::To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondrial translation inhibition as the mechanism of tigecycline-mediated lethality. Tigecycline selective...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.10.015
更新日期:2011-11-15 00:00:00
abstract::Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2014.06.026
更新日期:2014-08-11 00:00:00
abstract::Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion....
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.11.012
更新日期:2012-12-11 00:00:00
abstract::We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed b...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(04)00021-2
更新日期:2004-02-01 00:00:00
abstract::Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.05.020
更新日期:2016-07-11 00:00:00
abstract::The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.08.008
更新日期:2006-09-01 00:00:00
abstract::DNA microarrays make possible the rapid and comprehensive assessment of the transcriptional activity of a cell, and as such have proven valuable in assessing the molecular contributors to biological processes and in the classification of human cancers. The major challenge in using this technology is the analysis of it...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00181-2
更新日期:2002-11-01 00:00:00
abstract::Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 tha...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2010.10.001
更新日期:2010-10-19 00:00:00