Abstract:
:In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote liver-tumor aggressiveness in an NRF2-dependent manner.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Ramadori P,Li X,Heikenwalder Mdoi
10.1016/j.ccell.2020.07.003subject
Has Abstractpub_date
2020-08-10 00:00:00pages
152-154issue
2eissn
1535-6108issn
1878-3686pii
S1535-6108(20)30364-0journal_volume
38pub_type
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