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Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling.

Abstract：

:The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with early onset. Overexpressing Epm2a suppressed the growth of established tumor cells and the development of lymphoma in the TG-B mice, while specific silencing of the locus increased tumorigenesis in the immune-deficient host. Downregulation of Epm2a expression is widespread among mouse and human lymphoma cell lines. Epm2a-encoded laforin is a phosphatase for GSK-3beta and an important repressor in the Wnt signaling pathway. Inactivation of Epm2a resulted in increased Wnt signaling and tumorigenesis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Wang Y,Liu Y,Wu C,Zhang H,Zheng X,Zheng Z,Geiger TL,Nuovo GJ,Liu Y,Zheng P

doi

10.1016/j.ccr.2006.08.008

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

179-90

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(06)00249-2

journal_volume

10

pub_type

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