Same Script, Different Cast: Different Cell Origins Shape Molecular Features and Therapeutic Response in Glioblastoma.

Abstract:

:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Wu S,Mischel PS

doi

10.1016/j.ccell.2020.08.012

subject

Has Abstract

pub_date

2020-09-14 00:00:00

pages

311-313

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(20)30423-2

journal_volume

38

pub_type

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