Abstract:
:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from identical driver mutations.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Wu S,Mischel PSdoi
10.1016/j.ccell.2020.08.012subject
Has Abstractpub_date
2020-09-14 00:00:00pages
311-313issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(20)30423-2journal_volume
38pub_type
杂志文章相关文献
CANCER CELL文献大全abstract::The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of TAK1 in liver parenchymal cells (hepatocytes and cholangiocytes) causes hepatoc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.03.021
更新日期:2010-05-18 00:00:00
abstract::Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion....
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.11.012
更新日期:2012-12-11 00:00:00
abstract::In this study, we show that the formation of polyploidy following sustained mitotic checkpoint activation appears to be preceded by the ubiquitin-dependent proteolysis of hBubR1. In addition, the level of hBubR1 is significantly reduced not only in polyploid cells created by sustained mitotic spindle damage, but also ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(03)00302-7
更新日期:2003-12-01 00:00:00
abstract::In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 statu...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.04.010
更新日期:2016-05-09 00:00:00
abstract::8p11 myeloproliferative syndrome (EMS) is a hematopoietic stem cell disorder characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with t...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(04)00053-4
更新日期:2004-03-01 00:00:00
abstract::Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, a...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2020.03.008
更新日期:2020-04-13 00:00:00
abstract::Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.03.021
更新日期:2018-05-14 00:00:00
abstract::In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.04.032
更新日期:2012-05-15 00:00:00
abstract::Inhibition of ERK-MAPK signaling by expression of dominant-negative MEK1 in the tumor vasculature suppresses angiogenesis and tumor growth. In an organotypic tissue culture angiogenesis assay, ERK-MAPK inhibition during the migratory phase results in loss of bipolarity, detachment, and cell death of isolated endotheli...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.12.021
更新日期:2006-01-01 00:00:00
abstract::Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissect...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.10.018
更新日期:2009-12-08 00:00:00
abstract::We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 t...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.09.003
更新日期:2012-10-16 00:00:00
abstract::The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers show that the molecular signature of VHL(-/-) kidney cancers is profoundly influenced by whether they...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2008.11.005
更新日期:2008-12-09 00:00:00
abstract::In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lk...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.04.026
更新日期:2010-06-15 00:00:00
abstract::Solid tumors require new blood vessels for growth and metastasis, yet the biology of tumor-specific endothelial cells is poorly understood. We have isolated tumor endothelial cells from mice that spontaneously develop prostate tumors. Clonal populations of tumor endothelial cells expressed hematopoietic and mesenchyma...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.06.017
更新日期:2008-09-09 00:00:00
abstract::The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.02.013
更新日期:2017-04-10 00:00:00
abstract::In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.07.003
更新日期:2020-08-10 00:00:00
abstract::Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.09.003
更新日期:2014-10-13 00:00:00
abstract::The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.12.012
更新日期:2020-02-10 00:00:00
abstract::Overexpression of Bcl-xL, loss of p19 ARF, and loss of p53 all accelerate Myc oncogenesis. All three lesions are implicated in suppressing Myc-induced apoptosis, suggesting that this is a common mechanism by which they synergize with Myc. However, using an acutely switchable model of Myc-induced tumorigenesis, we demo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.06.017
更新日期:2006-08-01 00:00:00
abstract::Mdmx is a critical negative regulator of the p53 pathway that is stoichiometrically limiting in some tissues. Posttranslational modification and degradation of Mdmx after DNA damage have been proposed to be essential for p53 activation. We tested this model in vivo, where critical stoichiometric relationships are pres...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.05.008
更新日期:2009-07-07 00:00:00
abstract::It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.01.009
更新日期:2007-02-01 00:00:00
abstract::Unresponsiveness to therapy is a hallmark feature of advanced metastatic melanoma. However, the discovery of BRAF-activating mutations in approximately 50% of human melanomas has provided an attractive therapeutic target. Here, we discuss two recent publications focusing on the mutant BRAF kinase inhibitor PLX4032 tha...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2010.10.001
更新日期:2010-10-19 00:00:00
abstract::Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for overexpressed molecules with tolerable systemic expression. We integrated large trans...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.09.004
更新日期:2017-10-09 00:00:00
abstract::Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitant...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.01.027
更新日期:2009-03-03 00:00:00
abstract::Recent evidence suggests that human cells require more genetic changes for neoplastic transformation than do their murine counterparts. However, a precise enumeration of these differences has never been undertaken. We have determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tu...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.07.009
更新日期:2004-08-01 00:00:00
abstract::The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.09.018
更新日期:2016-10-10 00:00:00
abstract::Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration o...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.03.001
更新日期:2012-03-20 00:00:00
abstract::Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.09.012
更新日期:2017-10-09 00:00:00
abstract::PPARgamma is a member of the nuclear receptor family for which agonist ligands have antigrowth effects. However, clinical studies using PPARgamma ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARgamma activation with chemotherapeutic agents in current use for specifi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.025
更新日期:2007-05-01 00:00:00
abstract::In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.10.012
更新日期:2017-11-13 00:00:00