Abstract:
:A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Zhao C,Blum J,Chen A,Kwon HY,Jung SH,Cook JM,Lagoo A,Reya Tdoi
10.1016/j.ccr.2007.11.003subject
Has Abstractpub_date
2007-12-01 00:00:00pages
528-41issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(07)00334-0journal_volume
12pub_type
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