Differential utilization of two ATP-generating pathways is regulated by p53.

abstract：:Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for react...

journal_title：Cancer cell

authors： Hupp TR,Hayward RL,Vojtesek B

更新日期：2012-09-11 00:00:00

abstract：:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...

journal_title：Cancer cell

authors： Lees-Miller SP

更新日期：2008-05-01 00:00:00

abstract：:Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast majority of cells. Few surviving pre-B cell clones had acquired permissiveness to oncogenic signaling by strong activation of negative feedback regulation of Erk si...

journal_title：Cancer cell

authors： Shojaee S,Caeser R,Buchner M,Park E,Swaminathan S,Hurtz C,Geng H,Chan LN,Klemm L,Hofmann WK,Qiu YH,Zhang N,Coombes KR,Paietta E,Molkentin J,Koeffler HP,Willman CL,Hunger SP,Melnick A,Kornblau SM,Müschen M

更新日期：2015-07-13 00:00:00

abstract：:Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein...

journal_title：Cancer cell

authors： Lu G,Zhang Q,Huang Y,Song J,Tomaino R,Ehrenberger T,Lim E,Liu W,Bronson RT,Bowden M,Brock J,Krop IE,Dillon DA,Gygi SP,Mills GB,Richardson AL,Signoretti S,Yaffe MB,Kaelin WG Jr

更新日期：2014-08-11 00:00:00

abstract：:Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, ...

journal_title：Cancer cell

authors： Wolf MJ,Adili A,Piotrowitz K,Abdullah Z,Boege Y,Stemmer K,Ringelhan M,Simonavicius N,Egger M,Wohlleber D,Lorentzen A,Einer C,Schulz S,Clavel T,Protzer U,Thiele C,Zischka H,Moch H,Tschöp M,Tumanov AV,Haller D,Ung

更新日期：2014-10-13 00:00:00

abstract：:Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected mechanism for ligand-induced receptor dimerization that has important implications for activation and inhibition of these receptors. Here we describe the 2.8 angstroms resolution X-ray crysta...

journal_title：Cancer cell

authors： Li S,Schmitz KR,Jeffrey PD,Wiltzius JJ,Kussie P,Ferguson KM

更新日期：2005-04-01 00:00:00

abstract：:Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affec...

journal_title：Cancer cell

authors： McCormick F

更新日期：2018-02-12 00:00:00

abstract：:Abnormal activation of the epidermal growth factor receptor (EGFR) and its homolog HER2 (Neu/ErbB2) has been associated with many human cancers, and monoclonal antibodies targeting EGFR and HER2 are effective anticancer therapies. Structural studies of these receptors and antibodies have revealed much about how they f...

journal_title：Cancer cell

authors： Leahy DJ

更新日期：2008-04-01 00:00:00

abstract：:Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast, Myc activation-although producing a DDR as well-is known to primarily elicit an apoptotic countermeasure. Using the Emu-my...

journal_title：Cancer cell

authors： Reimann M,Lee S,Loddenkemper C,Dörr JR,Tabor V,Aichele P,Stein H,Dörken B,Jenuwein T,Schmitt CA

更新日期：2010-03-16 00:00:00

abstract：:MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC ch...

journal_title：Cancer cell

authors： Tu WB,Shiah YJ,Lourenco C,Mullen PJ,Dingar D,Redel C,Tamachi A,Ba-Alawi W,Aman A,Al-Awar R,Cescon DW,Haibe-Kains B,Arrowsmith CH,Raught B,Boutros PC,Penn LZ

更新日期：2018-10-08 00:00:00

abstract：:Two recent Lancet and Lancet Oncology papers report that cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have higher mortality rates. Common independent factors associated with increased risk of death were older age, history of smoking status, number of comorbidities, more a...

journal_title：Cancer cell

authors： Curigliano G

更新日期：2020-08-10 00:00:00

abstract：:Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization...

journal_title：Cancer cell

authors： Lim SO,Li CW,Xia W,Cha JH,Chan LC,Wu Y,Chang SS,Lin WC,Hsu JM,Hsu YH,Kim T,Chang WC,Hsu JL,Yamaguchi H,Ding Q,Wang Y,Yang Y,Chen CH,Sahin AA,Yu D,Hortobagyi GN,Hung MC

更新日期：2016-12-12 00:00:00

abstract：:Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typicall...

journal_title：Cancer cell

authors： Helming KC,Wang X,Roberts CWM

更新日期：2014-09-08 00:00:00

abstract：:It is believed that Mdm2 suppresses p53 in two ways: transcriptional inhibition by direct binding, and degradation via its E3 ligase activity. To study these functions physiologically, we generated mice bearing a single-residue substitution (C462A) abolishing the E3 function without affecting p53 binding. Unexpectedly...

journal_title：Cancer cell

authors： Itahana K,Mao H,Jin A,Itahana Y,Clegg HV,Lindström MS,Bhat KP,Godfrey VL,Evan GI,Zhang Y

更新日期：2007-10-01 00:00:00

abstract：:We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor ...

journal_title：Cancer cell

authors： Mun DG,Bhin J,Kim S,Kim H,Jung JH,Jung Y,Jang YE,Park JM,Kim H,Jung Y,Lee H,Bae J,Back S,Kim SJ,Kim J,Park H,Li H,Hwang KB,Park YS,Yook JH,Kim BS,Kwon SY,Ryu SW,Park DY,Jeon TY,Kim DH,Lee JH,Han SU,

更新日期：2019-01-14 00:00:00

abstract：:We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, because RAS is activated by BCR-ABL, in drug-resistant chronic myeloid leukemia (CML) cells, RAS activity persists in the pre...

journal_title：Cancer cell

authors： Packer LM,Rana S,Hayward R,O'Hare T,Eide CA,Rebocho A,Heidorn S,Zabriskie MS,Niculescu-Duvaz I,Druker BJ,Springer C,Marais R

更新日期：2011-12-13 00:00:00

abstract：:In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B ove...

journal_title：Cancer cell

authors： Li Q,Zhang X,Zhang Z

更新日期：2018-11-12 00:00:00

abstract：:E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...

journal_title：Cancer cell

authors： Deb G,Somervaille TCP

更新日期：2016-07-11 00:00:00

abstract：:The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, Fc-FcγR interactions have been shown to be important for mAb-directed effector ...

journal_title：Cancer cell

authors： Waight JD,Chand D,Dietrich S,Gombos R,Horn T,Gonzalez AM,Manrique M,Swiech L,Morin B,Brittsan C,Tanne A,Akpeng B,Croker BA,Buell JS,Stein R,Savitsky DA,Wilson NS

更新日期：2018-06-11 00:00:00

abstract：:Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been ...

journal_title：Cancer cell

authors： Aggarwal BB

更新日期：2004-09-01 00:00:00

abstract：:Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present an expression-based variant-impact phenotyping (eVIP) method ...

journal_title：Cancer cell

authors： Berger AH,Brooks AN,Wu X,Shrestha Y,Chouinard C,Piccioni F,Bagul M,Kamburov A,Imielinski M,Hogstrom L,Zhu C,Yang X,Pantel S,Sakai R,Watson J,Kaplan N,Campbell JD,Singh S,Root DE,Narayan R,Natoli T,Lahr DL,Tiro

更新日期：2016-08-08 00:00:00

abstract：:In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for th...

journal_title：Cancer cell

authors： Raabe EH,Eberhart CG

更新日期：2012-10-16 00:00:00

abstract：:Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. We defined two major genomic subtypes of primary stage Ta tumors. One of these was characterized by...

journal_title：Cancer cell

authors： Hurst CD,Alder O,Platt FM,Droop A,Stead LF,Burns JE,Burghel GJ,Jain S,Klimczak LJ,Lindsay H,Roulson JA,Taylor CF,Thygesen H,Cameron AJ,Ridley AJ,Mott HR,Gordenin DA,Knowles MA

更新日期：2017-11-13 00:00:00

abstract：:In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability. ...

journal_title：Cancer cell

authors： Naylor RM,van Deursen JM

更新日期：2017-02-13 00:00:00

abstract：:PUMA is a pro-apoptotic Bcl-2 family protein that can act as a tumor suppressor or oncogene in different cancers. In this issue, Kim et al. show that PUMA, independent of its apoptotic function, enforces glycolytic metabolism by inhibiting the transport of pyruvate into the mitochondria, promoting hepatocellular carci...

journal_title：Cancer cell

authors： Green DR

更新日期：2019-02-11 00:00:00

abstract：:The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...

journal_title：Cancer cell

authors： Zhang S,Zhao BS,Zhou A,Lin K,Zheng S,Lu Z,Chen Y,Sulman EP,Xie K,Bögler O,Majumder S,He C,Huang S

更新日期：2017-04-10 00:00:00

abstract：:Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of cancer-related deaths worldwide. It is well established that tobacco smoke is a tumor initiator, but we asked whether it also acts as a tumo...

journal_title：Cancer cell

authors： Takahashi H,Ogata H,Nishigaki R,Broide DH,Karin M

更新日期：2010-01-19 00:00:00

abstract：:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...

journal_title：Cancer cell

authors： Wu S,Mischel PS

更新日期：2020-09-14 00:00:00

abstract：:The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...

journal_title：Cancer cell

authors： Cheung EC,DeNicola GM,Nixon C,Blyth K,Labuschagne CF,Tuveson DA,Vousden KH

更新日期：2020-02-10 00:00:00

abstract：:Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 lead...

journal_title：Cancer cell

authors： Grinberg-Bleyer Y,Ghosh S

更新日期：2016-12-12 00:00:00