PIKK-ing a new partner: a new role for PKB in the DNA damage response.

Abstract:

:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-damaging agents, such as ionizing radiation. In a recent paper published in Molecular Cell, Hemmings and colleagues provide evidence that DNA-PK is required for the activation of PKB in response to exposure to ionizing radiation, suggesting that these two protein kinases may act together to promote survival after DNA damage.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Lees-Miller SP

doi

10.1016/j.ccr.2008.04.010

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

379-80

issue

5

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(08)00127-X

journal_volume

13

pub_type

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