Abstract:
:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-damaging agents, such as ionizing radiation. In a recent paper published in Molecular Cell, Hemmings and colleagues provide evidence that DNA-PK is required for the activation of PKB in response to exposure to ionizing radiation, suggesting that these two protein kinases may act together to promote survival after DNA damage.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Lees-Miller SPdoi
10.1016/j.ccr.2008.04.010subject
Has Abstractpub_date
2008-05-01 00:00:00pages
379-80issue
5eissn
1535-6108issn
1878-3686pii
S1535-6108(08)00127-Xjournal_volume
13pub_type
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