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c-Raf in KRas Mutant Cancers: A Moving Target.

Abstract：

:Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affecting MAPK signaling.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

McCormick F

doi

10.1016/j.ccell.2018.01.017

subject

Has Abstract

pub_date

2018-02-12 00:00:00

pages

158-159

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(18)30017-5

journal_volume

33

pub_type

评论,杂志文章

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