Abstract:
:Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-kappaB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Aggarwal BBdoi
10.1016/j.ccr.2004.09.003keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
203-8issue
3eissn
1535-6108issn
1878-3686pii
S1535610804002442journal_volume
6pub_type
杂志文章,评审相关文献
CANCER CELL文献大全abstract::The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2 mutations cause Noonan Syndrome (NS), which is associated with increased risk of juvenile myelomonocytic leukemia (JMML). Somatic Shp2 mutations occur in sporadic JMML and other leukemias. We found...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.01.010
更新日期:2005-02-01 00:00:00
abstract::The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.08.008
更新日期:2006-09-01 00:00:00
abstract::A recent report in Science from the Varmus laboratory (Podsypanina et al., 2008) puts an interesting twist on the origins of metastatic cells, suggesting that metastases can arise in ways that are very different from those widely believed. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.09.009
更新日期:2008-10-07 00:00:00
abstract::PML/RARalpha is of crucial importance in acute promyelocytic leukemia (APL) both pathologically and therapeutically. Using a genome-wide approach, we identified in vivo PML/RARalpha binding sites in a PML/RARalpha-inducible cell model. Of the 2979 targeted regions, >62% contained canonical PU.1 motifs and >84% of thes...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.12.045
更新日期:2010-02-17 00:00:00
abstract::Homeostasis under hypoxic conditions is maintained through a coordinated transcriptional response mediated by the hypoxia-inducible factor (HIF) pathway and requires coactivation by the CBP and p300 transcriptional coactivators. Through a target-based high-throughput screen, we identified chetomin as a disrupter of HI...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.06.009
更新日期:2004-07-01 00:00:00
abstract::The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT-medulloblastoma, an essentially curable form of the disease, induce an aberrant fenestrated vasculature that permits the accumulation of high levels o...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.03.002
更新日期:2016-04-11 00:00:00
abstract::Deregulation of growth factor receptor tyrosine kinases (RTKs) is linked to a large number of malignancies. This occurs through a variety of mechanisms that result in enhanced activity of the receptor. Considerable evidence now supports the idea that loss of negative regulation plays an important role in receptor dere...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(03)00136-3
更新日期:2003-06-01 00:00:00
abstract::Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2015.03.015
更新日期:2015-04-13 00:00:00
abstract::Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating β-catenin le...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.10.030
更新日期:2011-12-13 00:00:00
abstract::EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.09.004
更新日期:2013-10-14 00:00:00
abstract::Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.09.012
更新日期:2017-10-09 00:00:00
abstract::In this issue of Cancer Cell, Kudo et al. identify a novel tumor suppressor role for PKCλ/ι in hepatocellular carcinoma. Loss of PKCλ/ι in obesity-driven liver cancer results in cellular metabolic reprogramming that induces two reciprocally sustainable processes, oxidative phosphorylation and autophagy, which promote ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.07.003
更新日期:2020-08-10 00:00:00
abstract::The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this p...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2009.11.017
更新日期:2009-12-08 00:00:00
abstract::UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, including E3 ligase function, but the maintenance domains are poorly characterized. Here, we demonstrate that UHRF1 histone- and hemimethylated DNA binding functions, but not E3 li...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.03.003
更新日期:2019-04-15 00:00:00
abstract::HIF-2alpha promotes von Hippel-Lindau (VHL)-deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1alpha inhibits RCC growth. As HIF-1alpha antagonizes c-Myc function, we hypothesized that HIF-2alpha might enhance c-Myc activity. We demonstrate here that HIF-2alpha promotes cell-cycle progression in hypo...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2007.02.006
更新日期:2007-04-01 00:00:00
abstract::The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.04.010
更新日期:2008-05-01 00:00:00
abstract::Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperative...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.05.013
更新日期:2016-06-13 00:00:00
abstract::Tumorigenesis is often associated with an unbalanced protein homeostasis (proteostasis) network, which sensitizes cancer cells to drugs targeting protein quality control (PQC) regulators. In this issue of Cancer Cell, Anderson and colleagues investigated the anti-cancer activity of a new class of inhibitor against a m...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2015.10.006
更新日期:2015-11-09 00:00:00
abstract::Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of these metabolic programs is critical to successfully exploit them for therapy. Here, we report that the oncogenic melanocyte li...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.11.020
更新日期:2013-03-18 00:00:00
abstract::Mdmx is a critical negative regulator of the p53 pathway that is stoichiometrically limiting in some tissues. Posttranslational modification and degradation of Mdmx after DNA damage have been proposed to be essential for p53 activation. We tested this model in vivo, where critical stoichiometric relationships are pres...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.05.008
更新日期:2009-07-07 00:00:00
abstract::The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers show that the molecular signature of VHL(-/-) kidney cancers is profoundly influenced by whether they...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2008.11.005
更新日期:2008-12-09 00:00:00
abstract::Recent studies have identified genes and core pathways that are altered in human glioblastoma. However, the mechanisms by which alterations of these glioblastoma genes singly and cooperatively transform brain cells remain poorly understood. Further, the cell of origin of glioblastoma is largely elusive. By targeting a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2009.04.001
更新日期:2009-06-02 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2015.07.007
更新日期:2015-08-10 00:00:00
abstract::Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.01.021
更新日期:2012-04-17 00:00:00
abstract::The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific bind...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.07.006
更新日期:2016-08-08 00:00:00
abstract::Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully understood. Here, we report that the endogenous expression of oncogenic KRas suppresses premature senes...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.10.020
更新日期:2010-11-16 00:00:00
abstract::Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the r...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.10.006
更新日期:2013-11-11 00:00:00
abstract::Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into ...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2019.07.010
更新日期:2019-09-16 00:00:00
abstract::The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways. Here, we report that conditional ablation of TAK1 in liver parenchymal cells (hepatocytes and cholangiocytes) causes hepatoc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2010.03.021
更新日期:2010-05-18 00:00:00
abstract::LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metast...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.08.014
更新日期:2017-09-11 00:00:00