EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.

abstract：:Ras and pRb are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Adding to several previously established lines of communication between the two, in this issue of Cancer Cell, Shamma et al. resolve a new signaling network involved in cellular senescence a...

journal_title：Cancer cell

authors： Peeper DS

更新日期：2009-04-07 00:00:00

abstract：:Therapeutic resistance is a major challenge in cancer treatment. In this issue of Cancer Cell, Kurppa et al. demonstrated that a senescence-like state enables lung cancer cells to survive dual inhibition of EGFR and MEK. This was mediated by the YAP/TEAD pathway, which drives epigenomic reprogramming and EMT to counte...

journal_title：Cancer cell

authors： Bado I,Zhang XH

更新日期：2020-01-13 00:00:00

abstract：:Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affec...

journal_title：Cancer cell

authors： McCormick F

更新日期：2018-02-12 00:00:00

abstract：:One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...

journal_title：Cancer cell

authors： Vu LP,Kharas MG

更新日期：2018-09-10 00:00:00

abstract：:Women with ErbB2-positive breast cancer have a poor prognosis, and frequently, chemotherapy treatment is ineffective. The ErbB2-targeted antibody trastuzumab improves survival when given with chemotherapy to patients with ErbB2-overexpressing metastatic disease, but treatment is not curative, and primary resistance is...

journal_title：Cancer cell

authors： Crowder RJ,Lombardi DP,Ellis MJ

更新日期：2004-08-01 00:00:00

abstract：:Mechanisms for breast cancer recurrence and metastases are poorly understood. New evidence from a transgenic mouse mammary tumor model suggests that the transcriptional repressor, Snail, may play a role in recurrence by downregulating E-cadherin and inducing an epithelial-to-mesenchymal transition. Preliminary informa...

journal_title：Cancer cell

authors： Davidson NE,Sukumar S

更新日期：2005-09-01 00:00:00

abstract：:CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR ...

journal_title：Cancer cell

authors： Davies DM,Maher J

更新日期：2020-12-30 00:00:00

abstract：:Slit is a secreted protein known to function through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, and as an inhibitor in leukocyte chemotaxis. Here we show Slit2 expression in a large number of solid tumors and Robo1 expression in vascular endothelial cells. Recombinant S...

journal_title：Cancer cell

authors： Wang B,Xiao Y,Ding BB,Zhang N,Yuan Xb,Gui L,Qian KX,Duan S,Chen Z,Rao Y,Geng JG

更新日期：2003-07-01 00:00:00

abstract：:Mutations in the EGFR kinase are a cause of non-small-cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788, and a staurosporine. We find that ...

journal_title：Cancer cell

authors： Yun CH,Boggon TJ,Li Y,Woo MS,Greulich H,Meyerson M,Eck MJ

更新日期：2007-03-01 00:00:00

abstract：:Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unex...

journal_title：Cancer cell

authors： Hirsch HA,Iliopoulos D,Joshi A,Zhang Y,Jaeger SA,Bulyk M,Tsichlis PN,Shirley Liu X,Struhl K

更新日期：2010-04-13 00:00:00

abstract：:It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2...

journal_title：Cancer cell

authors： Hüsemann Y,Geigl JB,Schubert F,Musiani P,Meyer M,Burghart E,Forni G,Eils R,Fehm T,Riethmüller G,Klein CA

更新日期：2008-01-01 00:00:00

abstract：:The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...

journal_title：Cancer cell

authors： Bunda S,Zadeh G,Aldape KD

更新日期：2017-12-11 00:00:00

abstract：:Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...

journal_title：Cancer cell

authors： Schmitt AM,Chang HY

更新日期：2016-04-11 00:00:00

abstract：:Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. We defined two major genomic subtypes of primary stage Ta tumors. One of these was characterized by...

journal_title：Cancer cell

authors： Hurst CD,Alder O,Platt FM,Droop A,Stead LF,Burns JE,Burghel GJ,Jain S,Klimczak LJ,Lindsay H,Roulson JA,Taylor CF,Thygesen H,Cameron AJ,Ridley AJ,Mott HR,Gordenin DA,Knowles MA

更新日期：2017-11-13 00:00:00

abstract：:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...

journal_title：Cancer cell

authors： Lees-Miller SP

更新日期：2008-05-01 00:00:00

abstract：:MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele to address the imp...

journal_title：Cancer cell

authors： Post SM,Quintás-Cardama A,Pant V,Iwakuma T,Hamir A,Jackson JG,Maccio DR,Bond GL,Johnson DG,Levine AJ,Lozano G

更新日期：2010-09-14 00:00:00

abstract：:Inhibition of ERK-MAPK signaling by expression of dominant-negative MEK1 in the tumor vasculature suppresses angiogenesis and tumor growth. In an organotypic tissue culture angiogenesis assay, ERK-MAPK inhibition during the migratory phase results in loss of bipolarity, detachment, and cell death of isolated endotheli...

journal_title：Cancer cell

authors： Mavria G,Vercoulen Y,Yeo M,Paterson H,Karasarides M,Marais R,Bird D,Marshall CJ

更新日期：2006-01-01 00:00:00

abstract：:Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperative...

journal_title：Cancer cell

authors： Stromnes IM,Greenberg PD

更新日期：2016-06-13 00:00:00

abstract：:Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloi...

journal_title：Cancer cell

authors： Blobel GA,Kalota A,Sanchez PV,Carroll M

更新日期：2011-09-13 00:00:00

abstract：:The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...

journal_title：Cancer cell

authors： Wang Y,Liu Y,Wu C,Zhang H,Zheng X,Zheng Z,Geiger TL,Nuovo GJ,Liu Y,Zheng P

更新日期：2006-09-01 00:00:00

abstract：:Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of...

journal_title：Cancer cell

authors： Kaymak I,Williams KS,Cantor JR,Jones RG

更新日期：2021-01-11 00:00:00

abstract：:When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 instit...

journal_title：Cancer cell

authors： COVID-19 and Cancer Consortium. Electronic address: jeremy.warner@vumc.org.,COVID-19 and Cancer Consortium.

更新日期：2020-12-14 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are largely considered to foster cancer development despite wielding an arsenal of cytotoxic agents. Using a mouse model of PTEN-deficient uterine cancer, we describe a surprising inhibitory role for PMNs in epithelial carcinogenesis. By inducing tumor cell detachment from the base...

journal_title：Cancer cell

authors： Blaisdell A,Crequer A,Columbus D,Daikoku T,Mittal K,Dey SK,Erlebacher A

更新日期：2015-12-14 00:00:00

abstract：:During the course of tumor progression, cancer cells acquire a number of characteristic alterations. These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, an...

journal_title：Cancer cell

authors： Martin GS

更新日期：2003-09-01 00:00:00

abstract：:Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating β-catenin le...

journal_title：Cancer cell

authors： Damsky WE,Curley DP,Santhanakrishnan M,Rosenbaum LE,Platt JT,Gould Rothberg BE,Taketo MM,Dankort D,Rimm DL,McMahon M,Bosenberg M

更新日期：2011-12-13 00:00:00

abstract：:Adaptive resistance to PI3K-mTOR inhibitors potentially limits the clinical antitumor activities of these agents. In this issue of Cancer Cell, Britschgi and coworkers show that certain tumors acquire resistance to PI3K-mTOR inhibitors through activation of a JAK2-dependent pathway, leading to interleukin-8 secretion....

journal_title：Cancer cell

authors： Abraham RT

更新日期：2012-12-11 00:00:00

abstract：:Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...

journal_title：Cancer cell

authors： Zheng T,Ménard M,Weiss WA

更新日期：2017-10-09 00:00:00

abstract：:Human T cell leukemias can arise from oncogenes activated by specific chromosomal translocations involving the T cell receptor genes. Here we show that five different T cell oncogenes (HOX11, TAL1, LYL1, LMO1, and LMO2) are often aberrantly expressed in the absence of chromosomal abnormalities. Using oligonucleotide m...

journal_title：Cancer cell

authors： Ferrando AA,Neuberg DS,Staunton J,Loh ML,Huard C,Raimondi SC,Behm FG,Pui CH,Downing JR,Gilliland DG,Lander ES,Golub TR,Look AT

更新日期：2002-02-01 00:00:00

abstract：:The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...

journal_title：Cancer cell

authors： Lossos IS

更新日期：2007-09-01 00:00:00

abstract：:Activating mutations in the FLT3 receptor tyrosine kinase occur in 30% of patients with acute myeloid leukemia. Small molecule FLT3 kinase inhibitors show selective antitumor activity in preclinical models. Clinical studies are underway. ...

journal_title：Cancer cell

authors： Sawyers CL

更新日期：2002-06-01 00:00:00