Abstract:
:The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional factor, induced by the NF-kappaB canonical pathway, directly downregulates BCL6 expression. The authors further demonstrate that this negative regulatory mechanism may be disturbed in DLBCLs harboring BCL6 gene translocations or mutations. These finding suggest that IRF4 may function as a key regulator of germinal center reaction and a guardian of lymphomagenesis.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Lossos ISdoi
10.1016/j.ccr.2007.08.012subject
Has Abstractpub_date
2007-09-01 00:00:00pages
189-91issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(07)00237-1journal_volume
12pub_type
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