Abstract:
:The involvement of the homologous to E6-AP carboxyl terminus (HECT)-type E3s in crucial signaling pathways implicated in tumorigenesis is presently an area of intense research and extensive scientific interest. This review highlights recent discoveries on the ubiquitin-mediated degradation of crucial tumor suppressor molecules catalyzed by the HECT-type E3s. By providing a portrait of their protein targets, we intend to link the substrate specificity of HECT-type E3s with their contribution to tumorigenesis. Moreover, we discuss the relevance of targeting the HECT E3s, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Bernassola F,Karin M,Ciechanover A,Melino Gdoi
10.1016/j.ccr.2008.06.001subject
Has Abstractpub_date
2008-07-08 00:00:00pages
10-21issue
1eissn
1535-6108issn
1878-3686pii
S1535-6108(08)00191-8journal_volume
14pub_type
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