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The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.

Abstract：

:The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; considerable variance exists in the driving mutations, identifying markers, and evolutionary pressures influencing initiating cells in different individual tumors. Despite this, the ability to self-renew and differentiate must be conserved to reseed a heterogeneous tumor mass. Focusing on one example of a tumor-initiating cell population, we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties. This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Lubanska D,Market-Velker BA,deCarvalho AC,Mikkelsen T,Fidalgo da Silva E,Porter LA

doi

10.1016/j.ccr.2013.12.006

subject

Has Abstract

pub_date

2014-01-13 00:00:00

pages

64-76

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(13)00535-7

journal_volume

25

pub_type

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