Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.

abstract：:In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by breast cancer cells. These results provide a rationale for designing therapies targeting metastatic progression by disrupting its ...

journal_title：Cancer cell

authors： Matei I,Ghajar CM,Lyden D

更新日期：2011-08-16 00:00:00

abstract：:To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements o...

journal_title：Cancer cell

authors： Homminga I,Pieters R,Langerak AW,de Rooi JJ,Stubbs A,Verstegen M,Vuerhard M,Buijs-Gladdines J,Kooi C,Klous P,van Vlierberghe P,Ferrando AA,Cayuela JM,Verhaaf B,Beverloo HB,Horstmann M,de Haas V,Wiekmeijer AS,Pike-Over

更新日期：2011-04-12 00:00:00

abstract：:The mechanisms through which tumor antigen-specific T cells are elicited in natural or chemotherapy-induced immunosurveillance have been elusive. In this issue of Cancer Cell, two papers by Broz and colleagues and Ruffell and colleagues delineate an important role for a specific dendritic cell subset characterized by ...

journal_title：Cancer cell

authors： Zitvogel L,Kroemer G

更新日期：2014-11-10 00:00:00

abstract：:Mutant RAS-driven tumorigenesis was thought for decades to arise independently of wild-type RAS isoforms, but recent evidence indicates wild-type isoforms are involved. In this issue of Cancer Cell, Grabocka and colleagues report how the loss of wild-type RAS alters oncogenic signaling and dampens the DNA-damage respo...

journal_title：Cancer cell

authors： Anastassiadis T,Brown EJ

更新日期：2014-02-10 00:00:00

abstract：:It is widely accepted that metastasis is a late event in cancer progression. Here, however, we show that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women. Wild-type mice transplanted with single premalignant HER-2...

journal_title：Cancer cell

authors： Hüsemann Y,Geigl JB,Schubert F,Musiani P,Meyer M,Burghart E,Forni G,Eils R,Fehm T,Riethmüller G,Klein CA

更新日期：2008-01-01 00:00:00

abstract：:The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) a...

journal_title：Cancer cell

authors： Sherr CJ,McCormick F

更新日期：2002-08-01 00:00:00

abstract：:The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...

journal_title：Cancer cell

authors： Lees-Miller SP

更新日期：2008-05-01 00:00:00

abstract：:The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse...

journal_title：Cancer cell

authors： Hayakawa Y,Ariyama H,Stancikova J,Sakitani K,Asfaha S,Renz BW,Dubeykovskaya ZA,Shibata W,Wang H,Westphalen CB,Chen X,Takemoto Y,Kim W,Khurana SS,Tailor Y,Nagar K,Tomita H,Hara A,Sepulveda AR,Setlik W,Gershon MD,

更新日期：2015-12-14 00:00:00

abstract：:Glioblastoma is heterogeneous in the molecular subtypes based on transcriptomic classification. In this issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma, highlighting how the cell of origin generates distinct molecular landscapes and therapeutic vulnerabilities from i...

journal_title：Cancer cell

authors： Wu S,Mischel PS

更新日期：2020-09-14 00:00:00

abstract：:Neuropilin-1 (NRP1) guides the development of the nervous and vascular systems. Binding to either semaphorins or VEGF, NRP1 acts with plexins to regulate neuronal guidance, or with VEGFR2 to mediate vascular development. We have generated two monoclonal antibodies that bind to the Sema- and VEGF-binding domains of NRP...

journal_title：Cancer cell

authors： Pan Q,Chanthery Y,Liang WC,Stawicki S,Mak J,Rathore N,Tong RK,Kowalski J,Yee SF,Pacheco G,Ross S,Cheng Z,Le Couter J,Plowman G,Peale F,Koch AW,Wu Y,Bagri A,Tessier-Lavigne M,Watts RJ

更新日期：2007-01-01 00:00:00

abstract：:The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic ...

journal_title：Cancer cell

authors： Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C

更新日期：2017-04-10 00:00:00

abstract：:Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxyc...

journal_title：Cancer cell

authors： Shirai CL,Ley JN,White BS,Kim S,Tibbitts J,Shao J,Ndonwi M,Wadugu B,Duncavage EJ,Okeyo-Owuor T,Liu T,Griffith M,McGrath S,Magrini V,Fulton RS,Fronick C,O'Laughlin M,Graubert TA,Walter MJ

更新日期：2015-05-11 00:00:00

abstract：:Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may const...

journal_title：Cancer cell

authors： Moniz LS,Vanhaesebroeck B

更新日期：2014-10-13 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis remains elusive. We found that HOTTIP is aberrantly activated i...

journal_title：Cancer cell

authors： Luo H,Zhu G,Xu J,Lai Q,Yan B,Guo Y,Fung TK,Zeisig BB,Cui Y,Zha J,Cogle C,Wang F,Xu B,Yang FC,Li W,So CWE,Qiu Y,Xu M,Huang S

更新日期：2019-12-09 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation...

journal_title：Cancer cell

authors： Gabrilovich D,Nefedova Y

更新日期：2015-08-10 00:00:00

abstract：:Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient...

journal_title：Cancer cell

authors： Haemmerle M,Stone RL,Menter DG,Afshar-Kharghan V,Sood AK

更新日期：2018-06-11 00:00:00

abstract：:The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during...

journal_title：Cancer cell

authors： Kosmider O,Denis N,Lacout C,Vainchenker W,Dubreuil P,Moreau-Gachelin F

更新日期：2005-12-01 00:00:00

abstract：:Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present an expression-based variant-impact phenotyping (eVIP) method ...

journal_title：Cancer cell

authors： Berger AH,Brooks AN,Wu X,Shrestha Y,Chouinard C,Piccioni F,Bagul M,Kamburov A,Imielinski M,Hogstrom L,Zhu C,Yang X,Pantel S,Sakai R,Watson J,Kaplan N,Campbell JD,Singh S,Root DE,Narayan R,Natoli T,Lahr DL,Tiro

更新日期：2016-08-08 00:00:00

abstract：:Genital human papillomavirus (HPV) infection is causally linked to the development of cervical cancer, a leading cause of cancer-related mortality in women worldwide. Recent studies demonstrate the effectiveness of virus-like particle-based vaccines to induce neutralizing antibodies against HPV and prevent cervical in...

journal_title：Cancer cell

authors： Steller MA

更新日期：2003-01-01 00:00:00

abstract：:In this study, we show that the formation of polyploidy following sustained mitotic checkpoint activation appears to be preceded by the ubiquitin-dependent proteolysis of hBubR1. In addition, the level of hBubR1 is significantly reduced not only in polyploid cells created by sustained mitotic spindle damage, but also ...

journal_title：Cancer cell

authors： Shin HJ,Baek KH,Jeon AH,Park MT,Lee SJ,Kang CM,Lee HS,Yoo SH,Chung DH,Sung YC,McKeon F,Lee CW

更新日期：2003-12-01 00:00:00

abstract：:The telomere-stabilizing enzyme telomerase is induced in tumors and functionally associated with unlimited replicative potential. To further explore its necessity, transgenic mice expressing SV40 or HPV16 oncogenes, which elicit carcinomas in pancreas and skin, respectively, were rendered telomerase-deficient. Absence...

journal_title：Cancer cell

authors： Argilla D,Chin K,Singh M,Hodgson JG,Bosenberg M,de Solórzano CO,Lockett S,DePinho RA,Gray J,Hanahan D

更新日期：2004-10-01 00:00:00

abstract：:Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are particularly prevalent, occurring in 20% of all human cancers. As these are typicall...

journal_title：Cancer cell

authors： Helming KC,Wang X,Roberts CWM

更新日期：2014-09-08 00:00:00

abstract：:Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as xenografts, relativ...

journal_title：Cancer cell

authors： Sheltzer JM,Ko JH,Replogle JM,Habibe Burgos NC,Chung ES,Meehl CM,Sayles NM,Passerini V,Storchova Z,Amon A

更新日期：2017-02-13 00:00:00

abstract：:Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances a...

journal_title：Cancer cell

authors： Shen Y,Wang X,Lu J,Salfenmoser M,Wirsik NM,Schleussner N,Imle A,Freire Valls A,Radhakrishnan P,Liang J,Wang G,Muley T,Schneider M,Ruiz de Almodovar C,Diz-Muñoz A,Schmidt T

更新日期：2020-06-08 00:00:00

abstract：:Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unex...

journal_title：Cancer cell

authors： Hirsch HA,Iliopoulos D,Joshi A,Zhang Y,Jaeger SA,Bulyk M,Tsichlis PN,Shirley Liu X,Struhl K

更新日期：2010-04-13 00:00:00

abstract：:We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized cyclic nucleotide phosphodiesterase activity effectively suppressed b...

journal_title：Cancer cell

authors： D'Angelo A,Garzia L,André A,Carotenuto P,Aglio V,Guardiola O,Arrigoni G,Cossu A,Palmieri G,Aravind L,Zollo M

更新日期：2004-02-01 00:00:00

abstract：:Deregulation of E2F1 activity and resistance to TGFbeta are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies. Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel wi...

journal_title：Cancer cell

authors： Petrocca F,Visone R,Onelli MR,Shah MH,Nicoloso MS,de Martino I,Iliopoulos D,Pilozzi E,Liu CG,Negrini M,Cavazzini L,Volinia S,Alder H,Ruco LP,Baldassarre G,Croce CM,Vecchione A

更新日期：2008-03-01 00:00:00

abstract：:The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...

journal_title：Cancer cell

authors： Bunda S,Zadeh G,Aldape KD

更新日期：2017-12-11 00:00:00

abstract：:Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving...

journal_title：Cancer cell

authors： de Andrea CE,Schalper KA,Sanmamed MF,Melero I

更新日期：2018-12-10 00:00:00

abstract：:Using sequential gene expression profiling (GEP) samples, we defined a major functional group related to drug resistance that contains chromosomal instability (CIN) genes. One CIN gene in particular, NEK2, was highly correlated with drug resistance, rapid relapse, and poor outcome in multiple cancers. Overexpressing N...

journal_title：Cancer cell

authors： Zhou W,Yang Y,Xia J,Wang H,Salama ME,Xiong W,Xu H,Shetty S,Chen T,Zeng Z,Shi L,Zangari M,Miles R,Bearss D,Tricot G,Zhan F

更新日期：2013-01-14 00:00:00