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A new TIPE of phosphoinositide regulator in cancer.

Abstract：

:Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may constitute a novel phosphoinositide metabolism regulator.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Moniz LS,Vanhaesebroeck B

doi

10.1016/j.ccell.2014.09.017

subject

Has Abstract

pub_date

2014-10-13 00:00:00

pages

443-4

issue

4

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(14)00380-8

journal_volume

26

pub_type

杂志文章

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