Abstract:
:The E2F family of transcription factors is critical for the control of cell cycle progression. We now show that the specific inactivation of E2F3 in mouse embryo fibroblasts (MEFs) results in a disruption of the centrosome duplication cycle. Loss of E2F3, but not E2F1, E2F2, E2F4, or E2F5 results in unregulated cyclin E-dependent kinase activity, defects in nucleophosmin B association with centrosomes, and premature centriole separation and duplication. Consequently, this defect leads to centrosome amplification, mitotic spindle defects, and aneuploidy. Our findings implicate the E2F3 transcription factor as an important link that orchestrates DNA and centrosome duplication cycles, ensuring the faithful transmission of genetic material to daughter cells.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Saavedra HI,Maiti B,Timmers C,Altura R,Tokuyama Y,Fukasawa K,Leone Gdoi
10.1016/s1535-6108(03)00083-7keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
333-46issue
4eissn
1535-6108issn
1878-3686pii
S1535610803000837journal_volume
3pub_type
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