Abstract：
:Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. now report that most tumor cells have a substantial reserve capacity to produce ATP by oxidative phosphorylation when glycolysis is suppressed. These new data add to mounting evidence that the high rate of glycolysis exhibited by most tumors is required to support cell growth rather than to compensate for defect(s) in mitochondrial function.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Bui T,Thompson CBdoi
10.1016/j.ccr.2006.05.012subject
Has Abstractpub_date
2006-06-01 00:00:00pages
419-20issue
6eissn
1535-6108issn
1878-3686pii
S1535-6108(06)00149-8journal_volume
9pub_type
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