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Metastatic colon cancer cells negotiate the intravasation Notch.

Abstract：

:In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Christofori G

doi

10.1016/j.ccr.2011.01.003

subject

Has Abstract

pub_date

2011-01-18 00:00:00

pages

6-8

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(11)00004-3

journal_volume

19

pub_type

评论,杂志文章

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