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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis.

Abstract：

:Multiple angiogenesis inhibitors have been therapeutically validated in preclinical cancer models, and several in clinical trials. Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis. Increased invasiveness is also seen by genetic ablation of the Vegf-A gene in both models, substantiating the results of the pharmacological inhibitors. The realization that potent angiogenesis inhibition can alter the natural history of tumors by increasing invasion and metastasis warrants clinical investigation, as the prospect has important implications for the development of enduring antiangiogenic therapies.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Pàez-Ribes M,Allen E,Hudock J,Takeda T,Okuyama H,Viñals F,Inoue M,Bergers G,Hanahan D,Casanovas O

doi

10.1016/j.ccr.2009.01.027

subject

Has Abstract

pub_date

2009-03-03 00:00:00

pages

220-31

issue

3

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(09)00034-8

journal_volume

15

pub_type

杂志文章

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