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Is NF-kappaB2/p100 a direct activator of programmed cell death?

Abstract：

:Transcription factor NF-kappaB has been implicated in cancer development due to its ability to upregulate expression of genes with potentially prooncogenic functions, such as cell cycle regulators and antiapoptotic proteins (Karin et al., 2002). A recent report by suggests that a structural motif, a death domain (DD), present in one of the mammalian NF-kappaB proteins, NF-kappaB2/p100, allows it to directly activate cell death in a transcription-independent manner. Further, it is suggested that loss of the proapoptotic function of NF-kappaB2/p100 is directly linked to its oncogenic activity in lymphomas.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Häcker H,Karin M

doi

10.1016/s1535-6108(02)00213-1

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

431-3

issue

6

eissn

1535-6108

issn

1878-3686

pii

S1535610802002131

journal_volume

2

pub_type

杂志文章,评审

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