Abstract:
:CAR-engineered T cell immunotherapy has proven transformative in selected hematological malignancies. However, solid tumors largely remain impervious to these approaches. In addressing this challenge, Srivastava et al. in this issue demonstrate that oxaliplatin-based lymphodepleting chemotherapy promotes enhanced CAR T cell recruitment to lung tumors, boosting therapeutic impact in combination with anti-PD-L1.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Davies DM,Maher Jdoi
10.1016/j.ccell.2020.12.019subject
Has Abstractpub_date
2020-12-30 00:00:00eissn
1535-6108issn
1878-3686pii
S1535-6108(20)30667-Xpub_type
杂志文章相关文献
CANCER CELL文献大全abstract::Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations in 50% (22 of 44) of resistant BCCs and show that these mutations maintain Hedgehog signaling in the presence of SMO inhibitors. Alterations include four ligand ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2015.02.002
更新日期:2015-03-09 00:00:00
abstract::The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid tumors. However, there are no guidelines for optimal scheduling of these therapies. Here we show that VEGFR2 blockade creates a "normalizati...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2004.10.011
更新日期:2004-12-01 00:00:00
abstract::Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate therapeutic strategies that improve clinical outcomes. We used experimental models and clinical databases to identify GATA2 as a regulator of chemotherapy resistance and tumorigenicity in this context. Mechanistically, direct upregu...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.11.013
更新日期:2015-02-09 00:00:00
abstract::Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven by GCLM, is required for cancer initiation. Genetic loss of Gclm prevents a tumor's ability to drive malignant transformation. Intriguingly, these findings can...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.11.019
更新日期:2015-02-09 00:00:00
abstract::Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.06.017
更新日期:2013-08-12 00:00:00
abstract::Agonistic antibodies specific for members of the tumor necrosis factor receptor protein family hold great promise for immunotherapy of cancer. In this issue of Cancer Cell, White and colleagues provide evidence that the human IgG2 subclass may represent a superior backbone for the use of these antibodies in human ther...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2014.12.010
更新日期:2015-01-12 00:00:00
abstract::A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1535-6108(03)00305-2
更新日期:2003-12-01 00:00:00
abstract::The protein kinase PKB/Akt has long been associated with regulating signaling pathways that promote cell survival and cell growth, for example, in response to growth factors. In contrast, the DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA damage and for cell survival after exposure to DNA-dama...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2008.04.010
更新日期:2008-05-01 00:00:00
abstract::Adenosine deaminase associated with RNA1 (ADAR1) deregulation contributes to therapeutic resistance in many malignancies. Here we show that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a maturation, which represses CDKN1A expression indirectly via EZH2, thereby accelerating cell-...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.11.017
更新日期:2019-01-14 00:00:00
abstract::Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2012.01.021
更新日期:2012-04-17 00:00:00
abstract::Immune checkpoint blockade therapies fail to induce responses in the majority of cancer patients, so how to increase the objective response rate becomes an urgent challenge. Here, we demonstrate that sufficient T cell infiltration in tumor tissues is a prerequisite for response to PD-L1 blockade. Targeting tumors with...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.02.004
更新日期:2016-03-14 00:00:00
abstract::The erythroleukemia developed by spi-1/PU.1 transgenic mice is a multistage process characterized by an early arrest of the proerythroblast differentiation followed later on by malignant transformation. Herein, we report the presence of acquired mutations in the SCF receptor gene (Kit) in 86% of tumors isolated during...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2005.11.009
更新日期:2005-12-01 00:00:00
abstract::In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by breast cancer cells. These results provide a rationale for designing therapies targeting metastatic progression by disrupting its ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2011.08.004
更新日期:2011-08-16 00:00:00
abstract::Adler et al., in a paper appearing in Nature Genetics, exploited the intersect of genetic information from expression profiles with that from array comparative genomic hybridization in human breast cancers to identify genes that may induce the transcription of the prognostic "wound response" expression signature. The ...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccr.2006.03.026
更新日期:2006-04-01 00:00:00
abstract::Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances a...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2020.05.005
更新日期:2020-06-08 00:00:00
abstract::DNA microarrays make possible the rapid and comprehensive assessment of the transcriptional activity of a cell, and as such have proven valuable in assessing the molecular contributors to biological processes and in the classification of human cancers. The major challenge in using this technology is the analysis of it...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/s1535-6108(02)00181-2
更新日期:2002-11-01 00:00:00
abstract::Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARC...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2019.02.002
更新日期:2019-03-18 00:00:00
abstract::In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for th...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2012.10.001
更新日期:2012-10-16 00:00:00
abstract::Androgen deprivation therapy (ADT) for advanced prostate cancer inexorably leads to resistance, and clinically useful biomarkers are lacking. The value of genetically engineered mice for coclinical studies is clearly demonstrated in a recent publication that reveals XAF1, XIAP, and SRD5A1 as novel predictive biomarker...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2013.06.007
更新日期:2013-07-08 00:00:00
abstract::A specific association with mixed lineage leukemias suggests that MLL oncoproteins may selectively target early multipotent hematopoietic progenitors or stem cells. We demonstrate here that a representative MLL fusion protein, MLL-GAS7, impairs the differentiation and enhances the in vitro growth of murine hematopoiet...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/s1535-6108(03)00019-9
更新日期:2003-02-01 00:00:00
abstract::Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic cells mature, thus coinciding with a decrease in HOX gene expression. We show that H3K79 methyltrans...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2014.10.009
更新日期:2014-12-08 00:00:00
abstract::The BCL6 gene is a key factor necessary for formation of germinal centers and is implicated in pathogenesis of diffuse large B cell lymphoma (DLBCL). In this issue of Cancer Cell, Saito and colleagues explore regulation of BCL6 gene expression by CD40-NF-kappaB signaling pathway and show that the IRF4 transcriptional ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.08.012
更新日期:2007-09-01 00:00:00
abstract::Although common cancer hallmarks are well established, lineage-restricted oncogenes remain less understood. Here, we report an inherent dependency of melanoma cells on the small GTPase RAB7, identified within a lysosomal gene cluster that distinguishes this malignancy from over 35 tumor types. Analyses in human cells,...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2014.04.030
更新日期:2014-07-14 00:00:00
abstract::The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.08.008
更新日期:2006-09-01 00:00:00
abstract::Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could rev...
journal_title:Cancer cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1535-6108(03)00339-8
更新日期:2004-01-01 00:00:00
abstract::A fundamental property of cancer cells is the preferential utilization of glycolysis over aerobic respiration to produce ATP. Renewed interest in understanding the mechanism underlying this metabolic shift in energy production is broadening our understanding of the relationship between cancer and cellular metabolism. ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccr.2006.06.014
更新日期:2006-07-01 00:00:00
abstract::Immune cells' metabolism influences their differentiation and function. Given that a complex interplay of environmental factors within the tumor microenvironment (TME) can have a profound impact on the metabolic activities of immune, stromal, and tumor cell types, there is emerging interest to advance understanding of...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2020.09.004
更新日期:2021-01-11 00:00:00
abstract::Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2007.05.004
更新日期:2007-06-01 00:00:00
abstract::One of the biggest challenges in treating acute myeloid leukemia (AML) is relapse of aggressive disease after treatment. In this issue of Cancer Cell, Boyd et al. characterize a molecularly distinct population of chemotherapy-induced transient leukemic regenerating cells (LRCs), which can be exploited to prevent AML r...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.08.012
更新日期:2018-09-10 00:00:00
abstract::In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential th...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccr.2009.09.012
更新日期:2009-10-06 00:00:00