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Wnt breakers in colon cancer.

Abstract：

:Beta-catenin and Tcf4 are the downstream effectors of the Wnt signaling cascade. In colorectal cancer, mutations in Wnt cascade genes such as APC lead to the inappropriate formation of beta-catenin/Tcf4 complexes. Earlier work has predicted that disruption of the beta-catenin/Tcf4 protein-protein interaction could revert the proliferative phenotype of colorectal cancer cells. In this issue of Cancer Cell, Shivdasani and colleagues have explored high-throughput screening of compound libraries in a search for small molecule inhibitors of the Wnt cascade. Ultimately, such inhibitors could become a novel class of smart anticancer drugs.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Clevers H

doi

10.1016/s1535-6108(03)00339-8

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

5-6

issue

1

eissn

1535-6108

issn

1878-3686

pii

S1535610803003398

journal_volume

5

pub_type

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