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Breaking news on fragile sites in cancer.

Abstract：

:Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and creates a compelling link between replication stress, transcription, and chromosome rearrangements.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Glover TW,Wilson TE

doi

10.1016/j.ccr.2013.01.017

subject

Has Abstract

pub_date

2013-02-11 00:00:00

pages

137-9

issue

2

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(13)00038-X

journal_volume

23

pub_type

评论,杂志文章

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