Abstract：
:Using sequential gene expression profiling (GEP) samples, we defined a major functional group related to drug resistance that contains chromosomal instability (CIN) genes. One CIN gene in particular, NEK2, was highly correlated with drug resistance, rapid relapse, and poor outcome in multiple cancers. Overexpressing NEK2 in cancer cells resulted in enhanced CIN, cell proliferation and drug resistance, while targeting NEK2 by NEK2 shRNA overcame cancer cell drug resistance and induced apoptosis in vitro and in a xenograft myeloma mouse model. High expression of NEK2 induced drug resistance mainly through activation of the efflux pumps. Thus, NEK2 represents a strong predictor for drug resistance and poor prognosis in cancer and could be an important target for cancer therapy.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Zhou W,Yang Y,Xia J,Wang H,Salama ME,Xiong W,Xu H,Shetty S,Chen T,Zeng Z,Shi L,Zangari M,Miles R,Bearss D,Tricot G,Zhan Fdoi
10.1016/j.ccr.2012.12.001subject
Has Abstractpub_date
2013-01-14 00:00:00pages
48-62issue
1eissn
1535-6108issn
1878-3686pii
S1535-6108(12)00514-4journal_volume
23pub_type
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