Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma.


:In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.


Cancer Cell


Cancer cell


Goding CR




Has Abstract


2016-05-09 00:00:00














  • Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

    abstract::Through in silico and other analyses, we identified FOXC1 as expressed in at least 20% of human AML cases, but not in normal hematopoietic populations. FOXC1 expression in AML was almost exclusively associated with expression of the HOXA/B locus. Functional experiments demonstrated that FOXC1 contributes to a block in...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Somerville TD,Wiseman DH,Spencer GJ,Huang X,Lynch JT,Leong HS,Williams EL,Cheesman E,Somervaille TC

    更新日期:2015-09-14 00:00:00

  • Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

    abstract::The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cel...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Cheung EC,DeNicola GM,Nixon C,Blyth K,Labuschagne CF,Tuveson DA,Vousden KH

    更新日期:2020-02-10 00:00:00

  • 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.

    abstract::ErbB2, a metastasis-promoting oncoprotein, is overexpressed in approximately 25% of invasive/metastatic breast cancers, but in 50%-60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how a subset of ErbB2-overexpressing DCIS develops into invasive breast cancer (IBC). We found that co-overexpress...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Lu J,Guo H,Treekitkarnmongkol W,Li P,Zhang J,Shi B,Ling C,Zhou X,Chen T,Chiao PJ,Feng X,Seewaldt VL,Muller WJ,Sahin A,Hung MC,Yu D

    更新日期:2009-09-08 00:00:00

  • Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

    abstract::Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by expression of the p210-BCR-ABL fusion protein. We demonstrate in a murine model of p210-BCR-ABL-induced MPD that gene targeting of Rac1 and Rac2 significantly delays or abrogates disease development. Attenuation of the disease...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Thomas EK,Cancelas JA,Chae HD,Cox AD,Keller PJ,Perrotti D,Neviani P,Druker BJ,Setchell KD,Zheng Y,Harris CE,Williams DA

    更新日期:2007-11-01 00:00:00

  • A Novel Link between Inflammation and Cancer.

    abstract::Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 lead...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Grinberg-Bleyer Y,Ghosh S

    更新日期:2016-12-12 00:00:00

  • The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

    abstract::Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs have pleiotropic context-dependent functions that can translate into ...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Reina-Campos M,Diaz-Meco MT,Moscat J

    更新日期:2019-09-16 00:00:00

  • Nuclear factor-kappaB: the enemy within.

    abstract::Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been ...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Aggarwal BB

    更新日期:2004-09-01 00:00:00

  • Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all.

    abstract::A human pancreatic cancer progression model from intraepithelial neoplasia to ductal adenocarcinoma has been proposed. This process has been modeled in the mouse by activation of mutant Kras in pancreatic progenitor cells. In this issue of Cancer Cell, present a modification of their initial model by introducing a mut...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Siveke JT,Schmid RM

    更新日期:2005-05-01 00:00:00

  • Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

    abstract::Studying mechanisms of malignant transformation of human pre-B cells, we found that acute activation of oncogenes induced immediate cell death in the vast majority of cells. Few surviving pre-B cell clones had acquired permissiveness to oncogenic signaling by strong activation of negative feedback regulation of Erk si...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Shojaee S,Caeser R,Buchner M,Park E,Swaminathan S,Hurtz C,Geng H,Chan LN,Klemm L,Hofmann WK,Qiu YH,Zhang N,Coombes KR,Paietta E,Molkentin J,Koeffler HP,Willman CL,Hunger SP,Melnick A,Kornblau SM,Müschen M

    更新日期:2015-07-13 00:00:00

  • An animal model of MYC-driven medulloblastoma.

    abstract::Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here, we show that cerebellar stem cells expressi...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Pei Y,Moore CE,Wang J,Tewari AK,Eroshkin A,Cho YJ,Witt H,Korshunov A,Read TA,Sun JL,Schmitt EM,Miller CR,Buckley AF,McLendon RE,Westbrook TF,Northcott PA,Taylor MD,Pfister SM,Febbo PG,Wechsler-Reya RJ

    更新日期:2012-02-14 00:00:00

  • Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.

    abstract::Monosomy 7 and interstitial deletion of 7q (-7/7q-) are well-recognized nonrandom chromosomal abnormalities frequently found among patients with myelodysplastic syndromes (MDSs) and myeloid leukemias. We previously identified candidate myeloid tumor suppressor genes (SAMD9, SAMD9-like = SAMD9L, and Miki) in the 7q21.3...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Nagamachi A,Matsui H,Asou H,Ozaki Y,Aki D,Kanai A,Takubo K,Suda T,Nakamura T,Wolff L,Honda H,Inaba T

    更新日期:2013-09-09 00:00:00

  • Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.

    abstract::Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed in mice lacking the ubiquitin ligase Siah2, which regulates HIF-1alpha availability. Cooperation be...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Qi J,Nakayama K,Cardiff RD,Borowsky AD,Kaul K,Williams R,Krajewski S,Mercola D,Carpenter PM,Bowtell D,Ronai ZA

    更新日期:2010-07-13 00:00:00

  • Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines.

    abstract::Perturbation biology is a powerful approach to modeling quantitative cellular behaviors and understanding detailed disease mechanisms. However, large-scale protein response resources of cancer cell lines to perturbations are not available, resulting in a critical knowledge gap. Here we generated and compiled perturbed...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Zhao W,Li J,Chen MM,Luo Y,Ju Z,Nesser NK,Johnson-Camacho K,Boniface CT,Lawrence Y,Pande NT,Davies MA,Herlyn M,Muranen T,Zervantonakis IK,von Euw E,Schultz A,Kumar SV,Korkut A,Spellman PT,Akbani R,Slamon DJ,Gray

    更新日期:2020-12-14 00:00:00

  • Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

    abstract::The molecular mechanisms regulating leukemia-initiating cell (LIC) function are of important clinical significance. We use chronic myelogenous leukemia (CML) as a model of LIC-dependent malignancy and identify the interaction between the ubiquitin ligase Fbw7 and its substrate c-Myc as a regulator of LIC homeostasis. ...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Reavie L,Buckley SM,Loizou E,Takeishi S,Aranda-Orgilles B,Ndiaye-Lobry D,Abdel-Wahab O,Ibrahim S,Nakayama KI,Aifantis I

    更新日期:2013-03-18 00:00:00

  • The potential of new tumor endothelium-specific markers for the development of antivascular therapy.

    abstract::Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a ...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Li JL,Harris AL

    更新日期:2007-06-01 00:00:00

  • Of Snail, mice, and women.

    abstract::Mechanisms for breast cancer recurrence and metastases are poorly understood. New evidence from a transgenic mouse mammary tumor model suggests that the transcriptional repressor, Snail, may play a role in recurrence by downregulating E-cadherin and inducing an epithelial-to-mesenchymal transition. Preliminary informa...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Davidson NE,Sukumar S

    更新日期:2005-09-01 00:00:00

  • Ras and pRb: the relationship gets yet more intimate.

    abstract::Ras and pRb are key regulators of a plethora of cellular processes, including proliferation, differentiation, and tumorigenesis. Adding to several previously established lines of communication between the two, in this issue of Cancer Cell, Shamma et al. resolve a new signaling network involved in cellular senescence a...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Peeper DS

    更新日期:2009-04-07 00:00:00

  • Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.

    abstract::Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for overexpressed molecules with tolerable systemic expression. We integrated large trans...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Perna F,Berman SH,Soni RK,Mansilla-Soto J,Eyquem J,Hamieh M,Hendrickson RC,Brennan CW,Sadelain M

    更新日期:2017-10-09 00:00:00

  • Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling.

    abstract::The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with e...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Wang Y,Liu Y,Wu C,Zhang H,Zheng X,Zheng Z,Geiger TL,Nuovo GJ,Liu Y,Zheng P

    更新日期:2006-09-01 00:00:00

  • β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.

    abstract::Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating β-catenin le...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Damsky WE,Curley DP,Santhanakrishnan M,Rosenbaum LE,Platt JT,Gould Rothberg BE,Taketo MM,Dankort D,Rimm DL,McMahon M,Bosenberg M

    更新日期:2011-12-13 00:00:00

  • IRS-1: auditing the effectiveness of mTOR inhibitors.

    abstract::Rapamycin analogs that inhibit mTOR signaling have antitumor activity against certain lymphomas, but treatment of solid tumors has been less encouraging despite inhibition of mTOR function. Two recent papers give insight into the potential use of mTOR inhibitors. O'Reilly et al. provide evidence that poor tumor respon...

    journal_title:Cancer cell

    pub_type: 杂志文章,评审


    authors: Easton JB,Kurmasheva RT,Houghton PJ

    更新日期:2006-03-01 00:00:00

  • Cancer's sweet tooth.

    abstract::Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. ...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Bui T,Thompson CB

    更新日期:2006-06-01 00:00:00

  • miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

    abstract::To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive c...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Gaziel-Sovran A,Segura MF,Di Micco R,Collins MK,Hanniford D,Vega-Saenz de Miera E,Rakus JF,Dankert JF,Shang S,Kerbel RS,Bhardwaj N,Shao Y,Darvishian F,Zavadil J,Erlebacher A,Mahal LK,Osman I,Hernando E

    更新日期:2011-07-12 00:00:00

  • Glut3 Addiction: A Druggable Vulnerability in Glioblastoma.

    abstract::The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Bunda S,Zadeh G,Aldape KD

    更新日期:2017-12-11 00:00:00

  • Proteogenomic Characterization of Human Early-Onset Gastric Cancer.

    abstract::We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor ...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Mun DG,Bhin J,Kim S,Kim H,Jung JH,Jung Y,Jang YE,Park JM,Kim H,Jung Y,Lee H,Bae J,Back S,Kim SJ,Kim J,Park H,Li H,Hwang KB,Park YS,Yook JH,Kim BS,Kwon SY,Ryu SW,Park DY,Jeon TY,Kim DH,Lee JH,Han SU,

    更新日期:2019-01-14 00:00:00

  • DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.

    abstract::Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of c...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Takacova S,Slany R,Bartkova J,Stranecky V,Dolezel P,Luzna P,Bartek J,Divoky V

    更新日期:2012-04-17 00:00:00

  • Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.

    abstract::Mutational activation of KRas is the first and most frequently detected genetic lesion in pancreatic ductal adenocarcinoma (PDAC). However, the precise role of oncogenic KRas in the pathogenesis of PDAC is not fully understood. Here, we report that the endogenous expression of oncogenic KRas suppresses premature senes...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Lee KE,Bar-Sagi D

    更新日期:2010-11-16 00:00:00

  • Differential utilization of two ATP-generating pathways is regulated by p53.

    abstract::A fundamental property of cancer cells is the preferential utilization of glycolysis over aerobic respiration to produce ATP. Renewed interest in understanding the mechanism underlying this metabolic shift in energy production is broadening our understanding of the relationship between cancer and cellular metabolism. ...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Assaily W,Benchimol S

    更新日期:2006-07-01 00:00:00

  • Turning on a dimer: new insights into MLL chimeras.

    abstract::In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activa...

    journal_title:Cancer cell

    pub_type: 评论,杂志文章


    authors: Hsu K,Look AT

    更新日期:2003-08-01 00:00:00

  • Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

    abstract::Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein...

    journal_title:Cancer cell

    pub_type: 杂志文章


    authors: Lu G,Zhang Q,Huang Y,Song J,Tomaino R,Ehrenberger T,Lim E,Liu W,Bronson RT,Bowden M,Brock J,Krop IE,Dillon DA,Gygi SP,Mills GB,Richardson AL,Signoretti S,Yaffe MB,Kaelin WG Jr

    更新日期:2014-08-11 00:00:00