Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma.

Abstract:

:In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.

journal_name

Cancer Cell

journal_title

Cancer cell

authors

Goding CR

doi

10.1016/j.ccell.2016.04.010

subject

Has Abstract

pub_date

2016-05-09 00:00:00

pages

619-621

issue

5

eissn

1535-6108

issn

1878-3686

pii

S1535-6108(16)30168-4

journal_volume

29

pub_type

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