Abstract：
:Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of growth and survival, since Par3 deletion increases apoptosis and reduces growth in vivo and in vitro. In contrast, Par3-deficient mice are predisposed to formation of keratoacanthomas, cutaneous tumors thought to originate from different cellular origin and frequently observed in humans. Par3 expression is reduced in both mouse and human keratoacanthomas, indicating tumor-suppressive properties of Par3. Our results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Iden S,van Riel WE,Schäfer R,Song JY,Hirose T,Ohno S,Collard JGdoi
10.1016/j.ccr.2012.08.004subject
Has Abstractpub_date
2012-09-11 00:00:00pages
389-403issue
3eissn
1535-6108issn
1878-3686pii
S1535-6108(12)00352-2journal_volume
22pub_type
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