Abstract:
:Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By combining retroviral-mediated RNA interference with reexpression studies, we show that ongoing EWS/FLI expression is required for the tumorigenic phenotype of Ewing's sarcoma. We used this system to define the full complement of EWS/FLI-regulated genes in Ewing's sarcoma. Functional analysis revealed that NKX2.2 is an EWS/FLI-regulated gene that is necessary for oncogenic transformation in this tumor. Thus, we developed a highly validated transcriptional profile for the EWS/FLI fusion protein and identified a critical target gene in Ewing's sarcoma development.
journal_name
Cancer Celljournal_title
Cancer cellauthors
Smith R,Owen LA,Trem DJ,Wong JS,Whangbo JS,Golub TR,Lessnick SLdoi
10.1016/j.ccr.2006.04.004subject
Has Abstractpub_date
2006-05-01 00:00:00pages
405-16issue
5eissn
1535-6108issn
1878-3686pii
S1535-6108(06)00114-0journal_volume
9pub_type
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